Sleep in bipolar patients

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dc.contributor.authorGiglio, Larriany M. F.
dc.contributor.authorAndreazza, Ana C.
dc.contributor.authorAndersen, Monica Levy [UNIFESP]
dc.contributor.authorCereser, Keila M.
dc.contributor.authorWalz, Julio Cesar [UNIFESP]
dc.contributor.authorSterz, Laura [UNIFESP]
dc.contributor.authorKapczinski, Flavio
dc.contributor.institutionHosp Clin Porto Alegre
dc.contributor.institutionUniv Fed Rio Grande do Sul
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.date.accessioned2016-01-24T13:52:30Z
dc.date.available2016-01-24T13:52:30Z
dc.date.issued2009-05-01
dc.description.abstractSleep disturbance has been described in bipolar disorder (BPD). Specific complaints may include frequent nighttime awakenings, poor quality of sleep, reduction in total sleep time, and nightmares. Most patients with BPD also report insomnia when in depression, but a significant percentage of patients report hypersomnia symptoms with prolonged nighttime sleep, difficulty in wakening, and excessive daytime sleepiness.The present study aims to investigate whether bipolar patients with sleep disorders presented impairment in quality of life, disability, and global function.One hundred ninety bipolar patients type-I diagnosed by application of Structured Clinician Interview for DSM-IV Disorders (SCID), were distributed in two groups based on absence or presence of sleep disorders. Quality of life, disability, and global dysfunction were evaluated using the Health Organization's Quality of Life instrument (WHOQOL-Brief), the Sheehan Disability Scale, and the Global Assessment of Functioning (GAF), respectively.Sleep complaints have negative influence on general quality of life, observed by decreased scores in WHOQOL and GAF domains and increased Sheehan scores, indicating the importance of maintenance of normal sleep in bipolar patients.Our results suggest that sleep complains impair quality of life and global function. Collectively, further studies are warranted to investigate the impairment of sleep disturbance on others neurotrophic factors and neurochemical pathways.en
dc.description.affiliationHosp Clin Porto Alegre, Ctr Pesquisas, Bipolar Disorders Program, BR-90035003 Porto Alegre, RS, Brazil
dc.description.affiliationUniv Fed Rio Grande do Sul, ICBS, Dept Biochem, Porto Alegre, RS, Brazil
dc.description.affiliationUniversidade Federal de São Paulo, UNIFESP, Dept Psichobiol, São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, UNIFESP, Dept Psichobiol, São Paulo, Brazil
dc.description.sourceWeb of Science
dc.format.extent169-173
dc.identifierhttps://dx.doi.org/10.1007/s11325-008-0215-5
dc.identifier.citationSleep and Breathing. Heidelberg: Springer Heidelberg, v. 13, n. 2, p. 169-173, 2009.
dc.identifier.doi10.1007/s11325-008-0215-5
dc.identifier.issn1520-9512
dc.identifier.urihttps://repositorio.unifesp.br/handle/11600/31494
dc.identifier.wosWOS:000264841000008
dc.language.isoeng
dc.publisherSpringer
dc.relation.ispartofSleep and Breathing
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.rights.licensehttp://www.springer.com/open+access/authors+rights?SGWID=0-176704-12-683201-0
dc.subjectBipolar disorderen
dc.subjectSleepen
dc.subjectQuality of lifeen
dc.subjectInsomniaen
dc.subjectDisabilityen
dc.subjectGAFen
dc.titleSleep in bipolar patientsen
dc.typeinfo:eu-repo/semantics/article
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