Emerging sporotrichosis is driven by clonal and recombinant Sporothrix species

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dc.contributor.authorRodrigues, Anderson Messias [UNIFESP]
dc.contributor.authorSybren de Hoog, G.
dc.contributor.authorZhang, Yu
dc.contributor.authorCamargo, Zoilo Pires de [UNIFESP]
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.contributor.institutionKNAW Fungal Biodivers Ctr
dc.date.accessioned2016-01-24T14:37:17Z
dc.date.available2016-01-24T14:37:17Z
dc.date.issued2014-05-07
dc.description.abstractSporotrichosis, caused by agents of the fungal genus Sporothrix, occurs worldwide, but the infectious species are not evenly distributed. Sporothrix propagules usually gain entry into the warm-blooded host through minor trauma to the skin from contaminated plant debris or through scratches or bites from felines carrying the disease, generally in the form of outbreaks. Over the last decade, sporotrichosis has changed from a relatively obscure endemic infection to an epidemic zoonotic health problem. We evaluated the impact of the feline host on the epidemiology, spatial distribution, prevalence and genetic diversity of human sporotrichosis. Nuclear and mitochondrial markers revealed large structural genetic differences between S. brasiliensis and S. schenckii populations, suggesting that the interplay of host, pathogen and environment has a structuring effect on the diversity, frequency and distribution of Sporothrix species. Phylogenetic data support a recent habitat shift within S. brasiliensis from plant to cat that seems to have occurred in southeastern Brazil and is responsible for its emergence. A clonal structure was found in the early expansionary phase of the cathuman epidemic. However, the prevalent recombination structure in the plant-associated pathogen S. schenckii generates a diversity of genotypes that did not show any significant increase in frequency as etiological agents of human infection over time. These results suggest that closely related pathogens can follow different strategies in epidemics. Thus, species-specific types of transmission may require distinct public health strategies for disease control.en
dc.description.affiliationUniversidade Federal de São Paulo, Div Cell Biol, Dept Microbiol Immunol & Parasitol, BR-04023062 São Paulo, Brazil
dc.description.affiliationKNAW Fungal Biodivers Ctr, Centraalbureau Schimmelcultures, NL-3508 AD Utrecht, Netherlands
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Div Cell Biol, Dept Microbiol Immunol & Parasitol, BR-04023062 São Paulo, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipCoordenacao de Aperfeic, oamento de Pessoal de Nivel Superior
dc.description.sponsorshipNational Council for Scientific and Technological Development
dc.description.sponsorshipCoordenacao de Aperfeic, oamento de Pessoal de Nivel Superio
dc.description.sponsorshipIDFAPESP: 2011/07350-1
dc.description.sponsorshipIDFAPESP: 2009/54024-2
dc.description.sponsorshipIDCoordenacao de Aperfeic, oamento de Pessoal de Nivel Superior: BEX 2325/11-0
dc.description.sponsorshipIDNational Council for Scientific and Technological Development: 472600/2011-7
dc.format.extent10
dc.identifierhttp://dx.doi.org/10.1038/emi.2014.33
dc.identifier.citationEmerging Microbes & Infections. London: Nature Publishing Group, v. 3, 10 p., 2014.
dc.identifier.doi10.1038/emi.2014.33
dc.identifier.fileWOS000339238100002.pdf
dc.identifier.issn2222-1751
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/37764
dc.identifier.wosWOS:000339238100002
dc.language.isoeng
dc.publisherNature Publishing Group
dc.relation.ispartofEmerging Microbes & Infections
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectemerging infectious diseasesen
dc.subjectepidemiologyen
dc.subjectfungien
dc.subjectoutbreaken
dc.subjectSporothrixen
dc.subjectsporotrichosisen
dc.subjectzoonosisen
dc.titleEmerging sporotrichosis is driven by clonal and recombinant Sporothrix speciesen
dc.typeinfo:eu-repo/semantics/article
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