Midlife Hypertensive Status and Cognitive Function 20Years Later: the Southall and Brent Revisited Study

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dc.contributor.authorTaylor, Clare
dc.contributor.authorTillin, Therese
dc.contributor.authorChaturvedi, Nish
dc.contributor.authorDewey, Michael
dc.contributor.authorFerri, Cleusa Pinheiro [UNIFESP]
dc.contributor.authorHughes, Alun
dc.contributor.authorPrince, Martin
dc.contributor.authorRichards, Marcus
dc.contributor.authorShah, Ajit
dc.contributor.authorStewart, Robert
dc.contributor.institutionKings Coll London
dc.contributor.institutionUniv London Imperial Coll Sci Technol & Med
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.contributor.institutionMed Res Council Study Hlth & Dev
dc.contributor.institutionUniv Cent Lancashire
dc.date.accessioned2016-01-24T14:34:19Z
dc.date.available2016-01-24T14:34:19Z
dc.date.issued2013-09-01
dc.description.abstractObjectivesTo investigate long-term prospective associations between a range of measurements of hypertensive status in midlife and cognitive impairment 20 years later.DesignCohort study.SettingTwo areas (Southall and Brent) of northwest London.ParticipantsSurvey samples of a multiethnic population (European, African Caribbean, South Asian) aged 40 to 67 were followed up 20 years later.MeasurementsComprehensive cardiovascular assessments were performed at baseline, including measurements of resting blood pressure (BP) and, in a subsample, ambulatory BP. At follow-up, a battery of cognitive assessments was administered, and a composite outcome was derived, with impairment defined as the lowest 10% within each ethnic group. Logistic regression models were used to investigate associations with prior measures of hypertensive status.ResultsIn 1,484 participants at follow-up, cognitive impairment showed significant U-shaped associations with baseline diastolic BP (DBP) and mean arterial pressure (MAP; strongest for those aged >= 50 at baseline), independent of a range of covariates, but no associations were found with systolic BP or pulse pressure. Cognitive impairment was also associated with antihypertensive medication use and higher evening ambulatory DBP at baseline. No substantial differences in strengths of association were found between ethnic groups.ConclusionLow and high DBP and MAP were associated with cognitive impairment 20 years later. Higher evening DBP on ambulatory monitoring was also associated with greater risk.en
dc.description.affiliationKings Coll London, Inst Psychiat, London, England
dc.description.affiliationUniv London Imperial Coll Sci Technol & Med, Natl Heart & Lung Inst, London, England
dc.description.affiliationUniversidade Federal de São Paulo, Dept Psychiat, São Paulo, Brazil
dc.description.affiliationUniversidade Federal de São Paulo, Dept Psychobiol, São Paulo, Brazil
dc.description.affiliationMed Res Council Study Hlth & Dev, London, England
dc.description.affiliationUniv Cent Lancashire, Sch Hlth, Preston PR1 2HE, Lancs, England
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Dept Psychiat, São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Dept Psychobiol, São Paulo, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipWellcome Trust
dc.description.sponsorshipBritish Heart Foundation
dc.description.sponsorshipUK Medical Research Council
dc.description.sponsorshipDiabetes UK
dc.description.sponsorshipNational Institute for Health Research (NIHR) Biomedical Research Centre
dc.description.sponsorshipDementia Biomedical Research Unit at South London
dc.description.sponsorshipMaudsley NHS Foundation Trust
dc.description.sponsorshipKing's College London
dc.format.extent1489-1498
dc.identifierhttp://dx.doi.org/10.1111/jgs.12416
dc.identifier.citationJournal of the American Geriatrics Society. Hoboken: Wiley-Blackwell, v. 61, n. 9, p. 1489-1498, 2013.
dc.identifier.doi10.1111/jgs.12416
dc.identifier.fileWOS000324307200007.pdf
dc.identifier.issn0002-8614
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/36676
dc.identifier.wosWOS:000324307200007
dc.language.isoeng
dc.publisherWiley-Blackwell
dc.relation.ispartofJournal of the American Geriatrics Society
dc.rightsinfo:eu-repo/semantics/openAccess
dc.rights.licensehttp://olabout.wiley.com/WileyCDA/Section/id-406071.html
dc.subjectcognitive impairmenten
dc.subjectpulse pressureen
dc.subjectambulatory blood pressureen
dc.subjectblood pressureen
dc.subjecthypertensionen
dc.titleMidlife Hypertensive Status and Cognitive Function 20Years Later: the Southall and Brent Revisited Studyen
dc.typeinfo:eu-repo/semantics/article
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