Reduced frequency of CD4(+)CD25(HIGH)FOXP3(+) cells and diminished FOXP3 expression in patients with Common Variable Immunodeficiency: A link to autoimmunity?

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dc.contributor.authorGenre, J.
dc.contributor.authorErrante, P. R.
dc.contributor.authorKokron, C. M.
dc.contributor.authorToledo-Barros, M.
dc.contributor.authorCamara, N. O. S. [UNIFESP]
dc.contributor.authorRizzo, L. V.
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.date.accessioned2016-01-24T13:58:35Z
dc.date.available2016-01-24T13:58:35Z
dc.date.issued2009-08-01
dc.description.abstractCommon Variable Immunodeficiency (CVID) is a primary immunodeficiency disease characterized by defective immunoglobulin production and often associated with autoimmunity. We used flow cytometry to analyze CD4(+)CD25(HIGH)FOXP3(+) T regulatory (Treg) cells and ask whether perturbations in their frequency in peripheral blood could underlie the high incidence of autoimmune disorders in CVID patients. in this study, we report for the first time that CVID patients with autoimmune disease have a significantly reduced frequency of CD4(+)CD25(HIGH)FOXP3(+) cells in their peripheral blood accompanied by a decreased intensity of FOXP3 expression. Notably, although CVID patients in whom autoimmunity was not diagnosed had a reduced frequency of CD4(+)CD25(HIGH)FOXP3(+) cells, FOXP3 expression levels did not differ from those in healthy controls. in conclusion, these data suggest compromised homeostasis of CD4(+)CD25(HIGH)FOXP3(+) cells in a subset of CVID patients with autoimmunity, and may implicate Treg cells in pathological mechanisms of CVID. (C) 2009 Elsevier Inc. All rights reserved.en
dc.description.affiliationUniv São Paulo, Dept Immunol, Inst Biomed Sci, Lab Imunol Clin, BR-05508900 São Paulo, Brazil
dc.description.affiliationUniv São Paulo, Div Clin Immunol & Allergy, Sch Med, BR-05508900 São Paulo, Brazil
dc.description.affiliationUniv São Paulo, LIM 60, Sch Med, BR-05508900 São Paulo, Brazil
dc.description.affiliationUniversidade Federal de São Paulo, Div Nephrol, São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Div Nephrol, São Paulo, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.description.sponsorshipThe Brazilian Ministry of Science and Technology (MCT)
dc.description.sponsorshipInstituto do Milenio Programme
dc.description.sponsorshipIDFAPESP: 04/15887-1
dc.description.sponsorshipIDFAPESP: 07/07139-3
dc.format.extent215-221
dc.identifierhttp://dx.doi.org/10.1016/j.clim.2009.03.519
dc.identifier.citationClinical Immunology. San Diego: Academic Press Inc Elsevier Science, v. 132, n. 2, p. 215-221, 2009.
dc.identifier.doi10.1016/j.clim.2009.03.519
dc.identifier.issn1521-6616
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/31715
dc.identifier.wosWOS:000268269500008
dc.language.isoeng
dc.publisherElsevier B.V.
dc.relation.ispartofClinical Immunology
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.rights.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dc.subjectAutoimmunityen
dc.subjectCommon Variable Immunodeficiencyen
dc.subjectFOXP3en
dc.subjectRegulatory T cellsen
dc.titleReduced frequency of CD4(+)CD25(HIGH)FOXP3(+) cells and diminished FOXP3 expression in patients with Common Variable Immunodeficiency: A link to autoimmunity?en
dc.typeinfo:eu-repo/semantics/article
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