Role of muscarinic M1 receptors in inhibitory avoidance and contextual fear conditioning

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dc.contributor.authorKramer Soares, Juliana Carlota
dc.contributor.authorFornari, Raquel Vecchio
dc.contributor.authorMenezes Oliveira, Maria Gabriela
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.date.accessioned2016-01-24T12:41:26Z
dc.date.available2016-01-24T12:41:26Z
dc.date.issued2006-09-01
dc.description.abstractThe objective of the present study was to observe the effects of pre-training or post-training administration of dicyclomine, a M1 muscarinic antagonist, on inhibitory avoidance (IA) and contextual fear conditioning (CFC) and to investigate if the effects observed with the pre-training administration of dicyclomine are state-dependent. for each behavioral procedure (IA and CFC) groups of Wistar male rats were treated with saline or dicyclomine either 30 min before training (pre-training), immediately after training or 30 min before training/30 min before test (pre-training/pre-test). the animals were tested 24 h after training. the acquisition of IA and CFC was impaired by pre-training administration of dicyclomine. the consolidation of both tasks was not affected by dicyclomine given immediately after training. Pre-training/pre-test administration of dicyclomine impaired both tasks, an effect similar to that observed in the group which only received pre-training administration. Pre-test treatment induced dissociation between both tasks, impairing CFC retrieval, without interfering with the animals avoidance response. These results show that the dicyclomine did not affect IA and CFC consolidation, suggesting specific involvement of M1 muscarinic receptor only in acquisition these tasks, and these effects was not state-dependent. However, it is possible that the retrieval of these tasks may be mediated, at least in part, by different neurochemical mechanisms and may be dissociated by dicyclomine. (c) 2006 Elsevier Inc. All rights reserved.en
dc.description.affiliationUniversidade Federal de São Paulo, Dept Psicobiol, BR-04024002 São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Dept Psicobiol, BR-04024002 São Paulo, Brazil
dc.description.sourceWeb of Science
dc.format.extent188-196
dc.identifierhttp://dx.doi.org/10.1016/j.nlm.2006.02.006
dc.identifier.citationNeurobiology of Learning and Memory. San Diego: Academic Press Inc Elsevier Science, v. 86, n. 2, p. 188-196, 2006.
dc.identifier.doi10.1016/j.nlm.2006.02.006
dc.identifier.issn1074-7427
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/29135
dc.identifier.wosWOS:000240716800008
dc.language.isoeng
dc.publisherElsevier B.V.
dc.relation.ispartofNeurobiology of Learning and Memory
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.rights.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dc.subjectinhibitory avoidanceen
dc.subjectfear conditioningen
dc.subjectcholinergicen
dc.subjectM1 muscarinic receptoren
dc.subjectdicyclomineen
dc.titleRole of muscarinic M1 receptors in inhibitory avoidance and contextual fear conditioningen
dc.typeinfo:eu-repo/semantics/article
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