Exercise-Induced Change in Plasma IL-12p70 Is Linked to Migraine Prevention and Anxiolytic Effects in Treatment-Naive Women: A Randomized Controlled Trial

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dc.citation.issue6
dc.citation.volume24
dc.contributor.authorOliveira, Arao Belitardo [UNIFESP]
dc.contributor.authorLacerda Bachi, Andre Luis
dc.contributor.authorRibeiro, Reinaldo Teixeira
dc.contributor.authorMello, Marco Tulio
dc.contributor.authorVaisberg, Mauro [UNIFESP]
dc.contributor.authorPrieto Peres, Mario Fernando
dc.coverageBasel
dc.date.accessioned2020-07-17T14:03:17Z
dc.date.available2020-07-17T14:03:17Z
dc.date.issued2017
dc.description.abstractObjective: To conduct a randomized controlled trial to evaluate the effect of a 12-week aerobic exercise program for migraine prevention, plasma cytokines concentrations (TNF-alpha, interleukin [IL]-1 beta, IL-6, IL-8, IL-10, and IL-12p70), and anxiety in women with migraine. Methods: Women with episodic migraine (ICHD-II), aged between 20 and 50 years, who had never taken any prophylactic medication, and were physically inactive in the past 12 months were recruited from the university's hospital and a tertiary headache clinic between March 2012 and March 2015. Migraine attacks were recorded in headache diaries, cytokines were quantified by flow cytometry, and anxiety was assessed by the 7-item General Anxiety Disorder (GAD-7) scale. Blood sampling and psychometric interviews were undertaken on headache-free days. Results: Twenty participants ([mean +/- SD] age 33.8 +/- 10.5en
dc.description.abstractBMI 26 +/- 5.2) were randomly assigned and received intervention ("trained": n = 10) or entered on a waitlist ("inactive": n = 10). There were no differences between groups regarding patients' characteristics and baseline data. Days with migraine (p = 0.001), IL-12p70 levels (p = 0.036), and GAD-7 score (p = 0.034) were significantly reduced in the trained group after the intervention period, but there were no significant changes in these variables in the inactive group. There was no change in the levels of the other cytokines in either group. There were positive correlations between a reduction in IL-12p70 level and a reduction in the number of days with migraine (R-2 = 0.19, p = 0.045), and GAD-7 score (R-2 = 0.53, p < 0.001). Conclusion: The clinical and psychological therapeutic effects of aerobic exercise in treatment-naive women with migraine may involve the downregulation of IL-12p70. (C) 2018 S. Karger AG, Baselen
dc.description.affiliationUniv Fed Sao Paulo, Dept Neurol & Neurocirurgia, 669 Pedro de Toledo, BR-09039032 Sao Paulo, SP, Brazil
dc.description.affiliationInst Brasileiro Ensino Pesquisa Imunol Pulm & Exe, Sao Jose Dos Campos, Brazil
dc.description.affiliationUniv Fed Minas Gerais, Dept Ciencias Esporte, Belo Horizonte, MG, Brazil
dc.description.affiliationUniv Fed Sao Paulo, Dept Otorrinolaringol, Sao Paulo, Brazil
dc.description.affiliationHosp Israelita Albert Einstein, Brain Inst, Sao Paulo, Brazil
dc.description.affiliationUniv Sao Paulo, Hosp Clin, Inst Psiquiatria, Fac Med, Sao Paulo, Brazil
dc.description.affiliationUnifespUniv Fed Sao Paulo, Dept Neurol & Neurocirurgia, 669 Pedro de Toledo, BR-09039032 Sao Paulo, SP, Brazil
dc.description.affiliationUnifespUniv Fed Sao Paulo, Dept Otorrinolaringol, Sao Paulo, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipCoordenadoria de Aperfeicoamento de Pessoal de Nivel Superior (CAPES)
dc.format.extent293-299
dc.identifierhttp://dx.doi.org/10.1159/000487141
dc.identifier.citationNeuroimmunomodulation. Basel, v. 24, n. 6, p. 293-299, 2017.
dc.identifier.doi10.1159/000487141
dc.identifier.issn1021-7401
dc.identifier.urihttps://repositorio.unifesp.br/handle/11600/55273
dc.identifier.wosWOS:000433972600001
dc.language.isoeng
dc.publisherKarger
dc.relation.ispartofNeuroimmunomodulation
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.subjectMigraineen
dc.subjectChronic painen
dc.subjectPhysical activityen
dc.subjectCytokinesen
dc.subjectAnxietyen
dc.titleExercise-Induced Change in Plasma IL-12p70 Is Linked to Migraine Prevention and Anxiolytic Effects in Treatment-Naive Women: A Randomized Controlled Trialen
dc.typeinfo:eu-repo/semantics/article
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