Heterogeneidade clínica e coexistência das neuropatias diabéticas: diferenças e semelhanças entre diabetes melito tipos 1 e 2

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dc.contributor.authorRolim, Luiz Clemente de Souza Pereira [UNIFESP]
dc.contributor.authorSá, João Roberto de [UNIFESP]
dc.contributor.authorChacra, Antonio Roberto [UNIFESP]
dc.contributor.authorDib, Sergio Atala [UNIFESP]
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.date.accessioned2018-06-15T14:00:10Z
dc.date.available2018-06-15T14:00:10Z
dc.date.issued2009-10-01
dc.description.abstractObjective: To evaluate the heterogeneity and the coexistence of diabetic neuropathy (DNP) in type 1 (T1DM) and 2 (T2DM) diabetes mellitus. Methods: 74 T2DM and 20 T1DM patients were evaluated according to age (years), time from diagnosis of diabetes (TDD, years), body mass index (BMI, kg/m(2)), HbA1c and DNP type (American Diabetes Association criteria). Results: T1DM was younger (32.7 +/- 11.0 versus 56.9 +/- 10.3; p = 0.0001), leaner (BM: 23.6 +/- 3.85 versus 28.4 +/- 5.3; p = 0.0005) and they had longer TDD (171 +/- 9.7 versus 10.4 +/- 6.8; p = 0.003). Cardiovascular autonomic neuropathy (CAN) (60% versus 32.4%; p = 0.02) and its coexistence with polyneuropathy (PN) (62.5% versus 33.3%; p = 0.03) were more common in T1DM. Chronic painful polyneuropathy (CPP) was more prevalent in T2DM (60.8% versus 30.0%; p = 0.009). Logistic regression showed HbA1c as an independent variable related to PN (p = 0.04) in both groups. TDD (p = 0.03) and CPP (p = 0.003) were related to CAN in T1DM. Age (p = 0.0004) was related to CPP in T2DM. Conclusions: The DNP have shown a heterogeneity distribution in type 1 and type 2 diabetes mellitus. The related factors to different phenotypes of this complication, apart from hyperglycemia, may be variable between these two types of diabetes mellitus. Arq Bras Endocrinol Metalb. 2009;53(7):818-24en
dc.description.affiliationUniv Fed Sao Paulo, Escola Paulista Med, Ctr Diabet, Disciplina Endocrinol, Sao Paulo, Brazil
dc.description.affiliationUnifespUniv Fed Sao Paulo, Escola Paulista Med, Ctr Diabet, Disciplina Endocrinol, Sao Paulo, Brazil
dc.description.sourceWeb of Science
dc.format.extent818-824
dc.identifierhttp://dx.doi.org/10.1590/S0004-27302009000700005
dc.identifier.citationArquivos Brasileiros De Endocrinologia E Metabologia. Rio De Janeiro, Rj: Sbem-soc Brasil Endocrinologia & Metabologia, v. 53, n. 7, p. 818-824, 2009.
dc.identifier.doi10.1590/S0004-27302009000700005
dc.identifier.fileS0004-27302009000700005.pdf
dc.identifier.issn0004-2730
dc.identifier.scieloS0004-27302009000700005
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/42704
dc.identifier.wosWOS:000271389100005
dc.language.isopor
dc.publisherSbem-soc Brasil Endocrinologia & Metabologia
dc.relation.ispartofArquivos Brasileiros De Endocrinologia E Metabologia
dc.rightsAcesso aberto
dc.subjectDiabetes mellitusen
dc.subjectdiabetic neuropathiesen
dc.subjectdiagnosisen
dc.subjectprevalenceen
dc.titleHeterogeneidade clínica e coexistência das neuropatias diabéticas: diferenças e semelhanças entre diabetes melito tipos 1 e 2pt
dc.title.alternativeClinical heterogeneity and coexistence of diabetic neuropathies: difference and similarities between types 1 and 2 diabetes mellitusen
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