Peripubertal exposure to environmental enrichment prevents schizophrenia-like behaviors in the SHR strain animal model

Página do item simplificado
dc.citation.issue2/mar
dc.citation.volume176
dc.contributor.authorSantos, Camila Mauricio [UNIFESP]
dc.contributor.authorPeres, Fernanda Fiel [UNIFESP]
dc.contributor.authorDiana, Mariana Cepollaro [UNIFESP]
dc.contributor.authorJusti, Veronica [UNIFESP]
dc.contributor.authorSuiama, Mayra Akimi [UNIFESP]
dc.contributor.authorSantana, Marcela Goncalves [UNIFESP]
dc.contributor.authorAbilio, Vanessa Costhek [UNIFESP]
dc.coverageAmsterdam
dc.date.accessioned2020-07-31T12:47:40Z
dc.date.available2020-07-31T12:47:40Z
dc.date.issued2016
dc.description.abstractSchizophrenia is a highly disabling mental disorder, in which genetics and environmental factors interact culminating in the disease. The treatment of negative symptoms and cognitive deficits with antipsychotics is currently inefficient and is an important field of research. Environmental enrichment (EE) has been suggested to improve some cognitive deficits in animal models of various psychiatric disorders. In this study, we aimed to evaluate a possible beneficial effect of early and long-term exposure to EE on an animal model of schizophrenia, the SHR strain. Young male Wistar rats (control strain) and SHRs (21 post-natal days) were housed for 6 weeks in two different conditions: in large cages (10 animals per cage) containing objects of different textures, forms, colors and materials that were changed 3 times/week (EE condition) or in standard cages (5 animals per cage - Control condition). Behavioral evaluations - social interaction (SI), locomotion, prepulse inhibition of startle (PPI) and spontaneous alternation (SA) - were performed 6 weeks after the end of EE. SHRs presented deficits in PPI (a sensorimotor impairment), SI (mimicking the negative symptoms) and SA (a working memory deficit), and also hyperlocomotion (modeling the positive symptoms). EE was able to reduce locomotion and increase PPI in both strains, and to prevent the working memory deficit in SHRs. EE also increased the number of neurons in the CA1 and CA3 of the hippocampus. In conclusion, EE can be a potential nonpharmacological strategy to prevent some behavioral deficits associated with schizophrenia. (C) 2016 Elsevier B.V. All rights reserved.en
dc.description.affiliationUniv Fed Sao Paulo UNIFESP, LiNC Interdisciplinary Lab Clin Neurosci, Dept Psychiat, Rua Pedro de Toledo 669,3 Andar,Ed Pesquisas 2, BR-04039032 Sao Paulo, SP, Brazil
dc.description.affiliationUniv Fed Sao Paulo UNIFESP, Dept Pharmacol, Rua Pedro de Toledo 669,5 Andar,Ed Pesquisas 2, BR-04039032 Sao Paulo, SP, Brazil
dc.description.affiliationUnifespLiNC - Interdisciplinary Laboratory of Clinical Neurosciences, Department of Psychiatry, Universidade Federal de São Paulo (UNIFESP), Rua Pedro de Toledo, 669, 3° andar, Ed. de Pesquisas II, CEP 04039-032 São Paulo, SP, Brazil
dc.description.affiliationUnifespDepartment of Pharmacology, Universidade Federal de São Paulo (UNIFESP), Rua Pedro de Toledo, 669, 5° andar, Ed. de Pesquisas II, CEP 04039-032 São Paulo, SP, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.description.sponsorshipIDFAPESP: 2011/18851-1
dc.description.sponsorshipIDFAPESP: 2011/50740-5
dc.description.sponsorshipIDCNPq: 308241/2016-6
dc.format.extent552-559
dc.identifierhttp://dx.doi.org/10.1016/j.schres.2016.06.006
dc.identifier.citationSchizophrenia Research. Amsterdam, v. 176, n. 43526, p. 552-559, 2016.
dc.identifier.doi10.1016/j.schres.2016.06.006
dc.identifier.issn0920-9964
dc.identifier.urihttps://repositorio.unifesp.br/handle/11600/56991
dc.identifier.wosWOS:000384130200074
dc.language.isoeng
dc.publisherElsevier Science Bv
dc.relation.ispartofSchizophrenia Research
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.subjectSchizophreniaen
dc.subjectSHRen
dc.subjectAnimal modelen
dc.subjectEnvironmental enrichmenten
dc.subjectPPIen
dc.subjectSpontaneous alternationen
dc.titlePeripubertal exposure to environmental enrichment prevents schizophrenia-like behaviors in the SHR strain animal modelen
dc.typeinfo:eu-repo/semantics/article
Arquivos
Coleções
EPM - Artigos