Sex-related differences in COPD in five Latin American cities: the PLATINO study

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dc.contributor.authorLopez Varela, M. V.
dc.contributor.authorMontes de Oca, M.
dc.contributor.authorHalbert, R. J.
dc.contributor.authorMuino, A.
dc.contributor.authorPerez-Padilla, R.
dc.contributor.authorTalamo, C.
dc.contributor.authorJardim, Jose Roberto [UNIFESP]
dc.contributor.authorValdivia, G.
dc.contributor.authorPertuze, J.
dc.contributor.authorMoreno, D.
dc.contributor.authorMenezes, Ana Maria Baptista [UNIFESP]
dc.contributor.authorPLATINO Team
dc.contributor.institutionUniv Republica
dc.contributor.institutionCent Univ Venezuela
dc.contributor.institutionUniv Calif Los Angeles
dc.contributor.institutionInst Resp Dis
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.contributor.institutionUniv Fed Pelotas
dc.contributor.institutionPontificia Univ Catolica Chile
dc.date.accessioned2016-01-24T14:05:36Z
dc.date.available2016-01-24T14:05:36Z
dc.date.issued2010-11-01
dc.description.abstractThere is evidence to suggest sex differences exists in chronic obstructive pulmonary disease (COPD) clinical expression. We investigated sex differences in health status perception, dyspnoea and physical activity, and factors that explain these differences using an epidemiological sample of subjects with and without COPD.PLATINO is a cross-sectional, population-based study. We defined COPD as post-bronchodilator forced expiratory volume in 1 s/forced vital capacity ratio <0.70, and evaluated health status perception (Short Form (SF)-12 questionnaire) and dyspnoea (Medical Research Council scale).Among 5,314 subjects, 759 (362 females) had COPD and 4,555 (2,850 females) did not. in general, females reported more dyspnoea and physical limitation than males. 54% of females without COPD reported a dyspnoea score >= 2 versus 35% of males. A similar trend was observed in females with COPD (63% versus 44%). in the entire study population, female sex was a factor explaining dyspnoea (OR 1.60, 95% CI 1.40-1.84) and SF-12 physical score (OR -1.13, 95% CI -1.56- -0.71). 40% of females versus 28% of males without COPD reported their general health status as fair-to-poor. Females with COPD showed a similar trend (41% versus 34%). Distribution of COPD severity was similar between sexes, but currently smoking females had more severe COPD than currently smoking males.There are important sex differences in the impact that COPD has on the perception of dyspnoea, health status and physical activity limitation.en
dc.description.affiliationUniv Republica, Fac Med, Montevideo, Uruguay
dc.description.affiliationCent Univ Venezuela, Fac Med, Caracas, Venezuela
dc.description.affiliationUniv Calif Los Angeles, Sch Publ Hlth, Los Angeles, CA 90024 USA
dc.description.affiliationInst Resp Dis, Mexico City, DF, Mexico
dc.description.affiliationUniversidade Federal de São Paulo, São Paulo, Brazil
dc.description.affiliationUniv Fed Pelotas, Postgrad Program Epidemiol, Pelotas, Brazil
dc.description.affiliationPontificia Univ Catolica Chile, Santiago, Chile
dc.description.affiliationUnifespUniversidade Federal de São Paulo, São Paulo, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipBoehringer Ingelheim GmbH (Ingelheim, Germany)
dc.description.sponsorshipAsociacion Latinoamericana de Torax (ALAT)
dc.format.extent1034-1041
dc.identifierhttp://dx.doi.org/10.1183/09031936.00165409
dc.identifier.citationEuropean Respiratory Journal. Sheffield: European Respiratory Soc Journals Ltd, v. 36, n. 5, p. 1034-1041, 2010.
dc.identifier.doi10.1183/09031936.00165409
dc.identifier.issn0903-1936
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/33013
dc.identifier.wosWOS:000283669700012
dc.language.isoeng
dc.publisherEuropean Respiratory Soc Journals Ltd
dc.relation.ispartofEuropean Respiratory Journal
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectChronic pulmonary diseaseen
dc.subjectepidemiologyen
dc.subjecthealth statusen
dc.subjectsexen
dc.subjectsusceptibilityen
dc.titleSex-related differences in COPD in five Latin American cities: the PLATINO studyen
dc.typeinfo:eu-repo/semantics/article
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