Characterization of PVA/glutaraldehyde hydrogels obtained using Central Composite Rotatable Design (CCRD)

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dc.citation.issue4
dc.citation.volumev. 106
dc.contributor.authorMorandim-Giannetti, Andreia de Araujo
dc.contributor.authorRubio, Samantha Regina
dc.contributor.authorNogueira, Regina Freitas [UNIFESP]
dc.contributor.authorOrtega, Fernando dos Santos
dc.contributor.authorMagalhaes Junior, Octaviano [UNIFESP]
dc.contributor.authorSchor, Paulo [UNIFESP]
dc.contributor.authorBersanetti, Patricia Alessandra [UNIFESP]
dc.coverageHoboken
dc.date.accessioned2020-07-20T16:30:56Z
dc.date.available2020-07-20T16:30:56Z
dc.date.issued2018
dc.description.abstractHydrogels are made from natural or synthetic polymers and, currently, they have many biomedical applications. In this work, the conditions for obtaining a hydrogel with similar physicochemical characteristics to the vitreous humor were defined using polyvinyl alcohol (PVA) and glutaraldehyde (GLUT) as cross-linker. The concentration of PVA and GLUT were modified, and their effect was analyzed in terms of the refractive index, density, and dynamic viscosity. The hydrogel which was obtained using 3.98% (w/V) of PVA, 3.13 mL (1.57 g) of GLUT in 100 mL, and the initial pH of 7.2 showed similar characteristics to the vitreous humor (density= 1.0174 +/- 0.0050 g mL(-1), dynamic viscosity=3.7425 +/- 0.1800 mPa s and refractive index=1.3410 +/- 0.0010). The hydrogels were further investigated by rheological measurements, infrared spectroscopy, differential scanning calorimetry, X-ray diffraction and determination of swelling degree. The reticulation with GLUT promoted an increase in viscosity and glass transition temperature. On the other hand, it stimulated a decrease in the swelling degree, crystallinity, melting temperature, and intensity of the band related to the -OH bond, compared with the PVA without reticulation. The reticulated hydrogel displayed Newtonian behavior and a higher apparent viscosity than the PVA. (c) 2017 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 106B: 1558-1566, 2018.en
dc.description.affiliationCtr Univ FEI, Dept Engn Quim, Sao Bernardo Do Campo, Brazil
dc.description.affiliationUniv Fed Sao Paulo, Dept Oftalmol & Ciencias Visuais, Escola Paulista Med, Sao Paulo, Brazil
dc.description.affiliationCtr Univ FEI, Dept Engn Mat, Sao Bernardo Do Campo, Brazil
dc.description.affiliationUniv Fed Sao Paulo, Dept Bioquim, Escola Paulista Med, Sao Paulo, Brazil
dc.description.affiliationUnifespUniv Fed Sao Paulo, Dept Oftalmol & Ciencias Visuais, Escola Paulista Med, Sao Paulo, Brazil
dc.description.affiliationUnifespUniv Fed Sao Paulo, Dept Bioquim, Escola Paulista Med, Sao Paulo, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipSao Paulo Research Foundation (FAPESP)
dc.description.sponsorshipCentro Universitario FEI
dc.description.sponsorshipIDFAPESP: 2012/07343-8
dc.format.extent1558-1566
dc.identifierhttp://dx.doi.org/10.1002/jbm.b.33958
dc.identifier.citationJournal Of Biomedical Materials Research Part B-Applied Biomaterials. Hoboken, v. 106, n. 4, p. 1558-1566, 2018.
dc.identifier.doi10.1002/jbm.b.33958
dc.identifier.issn1552-4973
dc.identifier.urihttps://repositorio.unifesp.br/handle/11600/55596
dc.identifier.wosWOS:000430123100015
dc.language.isoeng
dc.publisherWiley
dc.relation.ispartofJournal Of Biomedical Materials Research Part B-Applied Biomaterials
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectdesign of experimentsen
dc.subjectglutaraldehydeen
dc.subjecthydrogelen
dc.subjectPVAen
dc.subjectvitreous humoren
dc.titleCharacterization of PVA/glutaraldehyde hydrogels obtained using Central Composite Rotatable Design (CCRD)en
dc.typeinfo:eu-repo/semantics/article
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