Intake of trans fatty acids during gestation and lactation leads to hypothalamic inflammation via TLR4/NF kappa Bp65 signaling in adult offspring

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dc.contributor.authorPimentel, Gustavo Duarte [UNIFESP]
dc.contributor.authorLira, Fabio Santos de [UNIFESP]
dc.contributor.authorRosa, Jose Cesar [UNIFESP]
dc.contributor.authorOliveira, Juliana Lopez de [UNIFESP]
dc.contributor.authorHachul, Ana Claudia Losinskas [UNIFESP]
dc.contributor.authorSouza, Gabriel Inacio Honorato de [UNIFESP]
dc.contributor.authorCarmo, Maria das Gracas Tavares do
dc.contributor.authorSantos, Ronaldo Vagner Thomatieli dos [UNIFESP]
dc.contributor.authorMello, Marco Tulio de [UNIFESP]
dc.contributor.authorTufik, Sergio [UNIFESP]
dc.contributor.authorSeelaender, Marilia [UNIFESP]
dc.contributor.authorOyama, Lila Missae [UNIFESP]
dc.contributor.authorNascimento, Claudia Maria da Penha Oller do [UNIFESP]
dc.contributor.authorWatanabe, Regina Lucia Harumi [UNIFESP]
dc.contributor.authorRibeiro, Eliane Beraldi [UNIFESP]
dc.contributor.authorPisani, Luciana Pellegrini [UNIFESP]
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.contributor.institutionUniversidade Federal do Rio de Janeiro (UFRJ)
dc.date.accessioned2016-01-24T14:26:55Z
dc.date.available2016-01-24T14:26:55Z
dc.date.issued2012-03-01
dc.description.abstractWe examined whether feeding pregnant and lactating rats with hydrogenated vegetable fats rich in trans fatty acids led to an increase in serum endotoxin levels and inflammation and to impaired satiety-sensing pathways in the hypothalamus of 90-day-old offspring. Pregnant and lactating Wistar rats were fed either a standard chow (Control) or one enriched with hydrogenated vegetable fat (Trans). Upon weaning, the male offspring were divided in two groups: Control-Control (CC), mothers and offspring fed the control diet; and Trans-Control (TC), mothers fed the trans diet, and offspring fed the control diet the offspring's food intake and body weight were quantified weekly and the offspring were killed on the 90th day of life by decapitation. the blood and hypothalamus were collected from the offspring. Food intake and body weight were higher in the TC rats than in the CC rats. TC rats had increased serum endotoxin levels and increased hypothalamic cytokines, IL-6, TNF-alpha and IL1-beta, concentrations (P<.05). TLR4, NF kappa Bp65 and MyD88 were higher (P <.05) in the TC rats than in the CC rats. AdipoR1 was lower in the TC rats than in the CC rats. Thus, the present study shows that the mothers' hydrogenated vegetable fat intake during pregnancy and lactation led to hypothalamic inflammation and impaired satiety-sensing, which promotes deleterious metabolic consequences such as obesity, even after the withdrawal of the causal factor. in other words, the effect remains after the consumption of the standard chow by offspring. (C) 2012 Elsevier Inc. All rights reserved.en
dc.description.affiliationUniversidade Federal de São Paulo, Dept Fisiol, São Paulo, Brazil
dc.description.affiliationUniv Fed Rio de Janeiro, Lab Bioquim Nutr, Inst Nutr Josue de Castro, Rio de Janeiro, RJ, Brazil
dc.description.affiliationUniversidade Federal de São Paulo, Dept Biociencias, Santos, SP, Brazil
dc.description.affiliationUniversidade Federal de São Paulo, Dept Psicobiol, São Paulo, Brazil
dc.description.affiliationUniversidade Federal de São Paulo, Inst Ciencias Biomed, Dept Biol Celular & Desenvolvimento, São Paulo, Brazil
dc.description.affiliationUniversidade Federal de São Paulo, Dept Ciencias Saude, Santos, SP, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Dept Fisiol, São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Dept Biociencias, Santos, SP, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Dept Psicobiol, São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Inst Ciencias Biomed, Dept Biol Celular & Desenvolvimento, São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Dept Ciencias Saude, Santos, SP, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.format.extent265-271
dc.identifierhttp://dx.doi.org/10.1016/j.jnutbio.2010.12.003
dc.identifier.citationJournal of Nutritional Biochemistry. New York: Elsevier B.V., v. 23, n. 3, p. 265-271, 2012.
dc.identifier.doi10.1016/j.jnutbio.2010.12.003
dc.identifier.issn0955-2863
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/34681
dc.identifier.wosWOS:000300914200008
dc.language.isoeng
dc.publisherElsevier B.V.
dc.relation.ispartofJournal of Nutritional Biochemistry
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.rights.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dc.subjectTrans fatty acidsen
dc.subjectHypothalamic inflammationen
dc.subjectCytokinesen
dc.subjectAdiponectin receptoren
dc.subjectFetal programmingen
dc.titleIntake of trans fatty acids during gestation and lactation leads to hypothalamic inflammation via TLR4/NF kappa Bp65 signaling in adult offspringen
dc.typeinfo:eu-repo/semantics/article
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