Levodopa Use and Sleep in Patients with Dementia with Lewy Bodies

dc.contributor.authorMolloy, Sophie
dc.contributor.authorMinett, Thais [UNIFESP]
dc.contributor.authorO'Brien, John T.
dc.contributor.authorMcKeith, Ian G.
dc.contributor.authorBurn, David J.
dc.contributor.institutionUniv Newcastle
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.date.accessioned2016-01-24T13:52:21Z
dc.date.available2016-01-24T13:52:21Z
dc.date.issued2009-03-15
dc.description.abstractSleep disturbance and excessive daytime somnolence (EDS) are features of Parkinson's disease (PD) and dementia with Lewy bodies (DLB) that may be influenced by dopamine replacement therapy. the effect of levodopa on sleep and EDS in DLB is unknown and unclear in PD. the aim of, this study is to determine if levodopa treatment alters sleep symptoms and EDS in DLB. Dopamine naive patients with DLB (n = 15: mean mini mental state examination (MMSE) score 17.7(4.6)) and PD (n = 9; mean MMSE 25.5(2.2)) were assessed using the Epworth sleep scale. Parkinson's disease sleep scale. and the neuropsychiatric inventory prior to initiating treatment with levodopa. All measures were repeated after 3 and 6 months of levodopa therapy. the median final daily levodopa dose was 300 mg in both groups. Baseline sleep measures were comparable between groups. Levodopa treatment did not affect sleep or lead to increased EDS in DLB patients. the use of levodopa does not appear to adversely affect subjective steep measures or increase EDS in DLB patients. (C) 2009 Movement Disorder Societyen
dc.description.affiliationUniv Newcastle, Wolfson Res Ctr, Inst Ageing & Hlth, Newcastle Upon Tyne, Tyne & Wear, England
dc.description.affiliationUniversidade Federal de São Paulo, Dept Prevent Med, São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Dept Prevent Med, São Paulo, Brazil
dc.description.sourceWeb of Science
dc.format.extent609-612
dc.identifierhttp://dx.doi.org/10.1002/mds.22411
dc.identifier.citationMovement Disorders. Hoboken: Wiley-liss, v. 24, n. 4, p. 609-612, 2009.
dc.identifier.doi10.1002/mds.22411
dc.identifier.issn0885-3185
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/31383
dc.identifier.wosWOS:000265003800019
dc.language.isoeng
dc.publisherWiley-Blackwell
dc.relation.ispartofMovement Disorders
dc.rightsAcesso restrito
dc.rights.licensehttp://olabout.wiley.com/WileyCDA/Section/id-406071.html
dc.subjectlevodopaen
dc.subjectsleepen
dc.subjectdementia with Lewy bodiesen
dc.titleLevodopa Use and Sleep in Patients with Dementia with Lewy Bodiesen
dc.typeArtigo
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