Saturated Fatty Acid Intake Can Influence Increase in Plasminogen Activator Inhibitor-1 in Obese Adolescents

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dc.contributor.authorMasquio, Deborah Cristina Landi [UNIFESP]
dc.contributor.authorPiano, Aline de [UNIFESP]
dc.contributor.authorCampos, Raquel Munhoz da Silveira [UNIFESP]
dc.contributor.authorSanches, Priscila de Lima [UNIFESP]
dc.contributor.authorCorgosinho, Flavia Campos [UNIFESP]
dc.contributor.authorCarnier, June [UNIFESP]
dc.contributor.authorOyama, Lila Missae [UNIFESP]
dc.contributor.authorNascimento, Claudia Maria da Penha Oller do [UNIFESP]
dc.contributor.authorMello, Marco Tulio de [UNIFESP]
dc.contributor.authorTufik, Sergio [UNIFESP]
dc.contributor.authorDâmaso, Ana Raimunda [UNIFESP]
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.date.accessioned2016-01-24T14:35:34Z
dc.date.available2016-01-24T14:35:34Z
dc.date.issued2014-04-01
dc.description.abstractThe aim of this study was to verify if saturated fatty acid intake adjusted by tertiles can influence metabolic, inflammation, and plasminogen activator inhibitor-1 (PAI-1) in obese adolescents. Body mass, height, body mass index, waist circumference, blood pressure, and body composition of 108 obese adolescents were obtained. Fasting glucose, insulin, PAI-1, and CRP were determined. Insulin resistance was assessed by Homeostasis Model Assessment (HOMA-IR) and insulin sensitivity by Quantitative Insulin Sensitivity Check Index (QUICKI). Dietetic intake was estimated by a 3-day dietary record, and volunteers were divided according to consumption of saturated fatty acids: tertile 1 [Low Saturated Fatty Acid Intake (Low-SFA): <= 12.14 g], tertile 2 [Moderate Saturated Fatty Intake (Moderate SFA intake): 12.15-20.48 g], and tertile 3 [High Saturated Fatty Acid Intake (High-SFA Intake); >20.48 g]. Statistical analysis was performed using STATISTICA 7.0 software and the significance level was set at p < 0.05. the most important finding in the present study is that Moderate and High-SFA intakes presented significantly higher values of PAI-1 than Low-SFA Intake. PAI-1 was positively associated with saturated fatty intake, waist circumference, mean blood pressure, and HOMA-IR. SFA intake was predictor of PAI-1 independent of body fat, HOMA-IR and total-cholesterol. in addition, PAI-1 was an independent predictor of blood pressure. HOMA-IR and QUICKI presented significantly higher and lower, respectively, in High-SFA compared to Moderate-SFA intake. High-SFA influenced cardiovascular disease risks, since it increased PAI-1 and insulin resistance, and decreased insulin sensibility, leading to vicious cycle among food ingestion, pro-thrombotic state, and cardiovascular risks in obese adolescents. Supporting Information for this article is available online at http://www.thieme-connect.de/ejournals/toc/hmren
dc.description.affiliationUniversidade Federal de São Paulo, Postgrad Program Nutr, São Paulo, Brazil
dc.description.affiliationUniversidade Federal de São Paulo, Dept Physiol, São Paulo, Brazil
dc.description.affiliationUniversidade Federal de São Paulo, Dept Psychobiol, São Paulo, Brazil
dc.description.affiliationUniversidade Federal de São Paulo, Dept Biosci, Santos, SP, Brazil
dc.description.affiliationUniversidade Federal de São Paulo, Postgrad Program Interdisciplinary Hlth Sci, Santos, SP, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Postgrad Program Nutr, São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Dept Physiol, São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Dept Psychobiol, São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Dept Biosci, Santos, SP, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Postgrad Program Interdisciplinary Hlth Sci, Santos, SP, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipUNIFESP
dc.description.sponsorshipAFIP
dc.description.sponsorshipCEPE
dc.description.sponsorshipCEMSA
dc.description.sponsorshipIDCNPq: 141533/2012-9
dc.description.sponsorshipIDCAPES: AUX-PE-PNPD 2566/2011
dc.description.sponsorshipIDFAPESP: 2011/50356-0
dc.description.sponsorshipIDFAPESP: 2011/50414-0
dc.description.sponsorshipIDFAPESP: 2013/041364
dc.format.extent245-251
dc.identifierhttps://dx.doi.org/10.1055/s-0034-1370908
dc.identifier.citationHormone and Metabolic Research. Stuttgart: Georg Thieme Verlag Kg, v. 46, n. 4, p. 245-251, 2014.
dc.identifier.doi10.1055/s-0034-1370908
dc.identifier.issn0018-5043
dc.identifier.urihttps://repositorio.unifesp.br/handle/11600/37636
dc.identifier.wosWOS:000337678800003
dc.language.isoeng
dc.publisherGeorg Thieme Verlag Kg
dc.relation.ispartofHormone and Metabolic Research
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.subjectObesityen
dc.subjectSaturated fatty intakeen
dc.subjectPAI-1en
dc.subjectInsulin resistanceen
dc.titleSaturated Fatty Acid Intake Can Influence Increase in Plasminogen Activator Inhibitor-1 in Obese Adolescentsen
dc.typeinfo:eu-repo/semantics/article
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