GCN2 activation and eIF2 alpha phosphorylation in the maturation of mouse oocytes

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dc.contributor.authorAlves, Viviane S. [UNIFESP]
dc.contributor.authorMotta, Fabiana L. [UNIFESP]
dc.contributor.authorRoffe, Martin [UNIFESP]
dc.contributor.authorDelamano, Arthur [UNIFESP]
dc.contributor.authorPesquero, Joao B. [UNIFESP]
dc.contributor.authorCastilho, Beatriz A. [UNIFESP]
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.date.accessioned2016-01-24T13:52:11Z
dc.date.available2016-01-24T13:52:11Z
dc.date.issued2009-01-02
dc.description.abstractGCN2 is one of the four mammalian kinases that phosphorylate the alpha subunit of the translation initiation factor 2 (eIF2 alpha) in a variety of stress situations, resulting in protein synthesis inhibition. GCN2 is involved in regulating metabolism, feeding behavior and memory in rodents. We show here that, relative to other cells, the beta isoform of the GCN2 transcript and the GCN2 protein are highly abundant in unfertilized mouse eggs. in addition, GCN2 in these cells is active, resulting in elevated levels of phosphorylated eIF2 alpha. After fertilization, eIF2 alpha phosphorylation decreases drastically. These results suggest that GCN2 mediated translational control may contribute to regulatory mechanisms operating during oocyte maturation. (C) 2008 Elsevier Inc. All rights reserved.en
dc.description.affiliationUniversidade Federal de São Paulo, Dept Microbiol Imunol & Parasitol, BR-86204023 São Paulo, Brazil
dc.description.affiliationUniversidade Federal de São Paulo, Dept Biofis, BR-86204023 São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Dept Microbiol Imunol & Parasitol, BR-86204023 São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Dept Biofis, BR-86204023 São Paulo, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.format.extent41-44
dc.identifierhttp://dx.doi.org/10.1016/j.bbrc.2008.10.161
dc.identifier.citationBiochemical and Biophysical Research Communications. San Diego: Academic Press Inc Elsevier Science, v. 378, n. 1, p. 41-44, 2009.
dc.identifier.doi10.1016/j.bbrc.2008.10.161
dc.identifier.issn0006-291X
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/31244
dc.identifier.wosWOS:000261779800009
dc.language.isoeng
dc.publisherElsevier B.V.
dc.relation.ispartofBiochemical and Biophysical Research Communications
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.rights.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dc.subjectOocyteen
dc.subjectGCN2en
dc.subjecteIF2en
dc.subjectProtein synthesisen
dc.subjectTranslational controlen
dc.titleGCN2 activation and eIF2 alpha phosphorylation in the maturation of mouse oocytesen
dc.typeinfo:eu-repo/semantics/article
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