ESSENTIAL-HYPERTENSION AND HISTOCOMPATIBILITY ANTIGENS - AN ASSOCIATION STUDY

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dc.contributor.authorGerbase-Lima, Maria [UNIFESP]
dc.contributor.authorLadalardo, Maria Antonia [UNIFESP]
dc.contributor.authorDelima, JJG
dc.contributor.authorSilva, H. B.
dc.contributor.authorBellotti, G.
dc.contributor.authorPileggi, F.
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.date.accessioned2018-06-15T17:35:11Z
dc.date.available2018-06-15T17:35:11Z
dc.date.issued1992-04-01
dc.description.abstractData from a previous study concerning the distribution of human leukocyte antigen (HLA) haplotypes in siblings with essential hypertension suggested that at least one of the genes responsible for the genetic susceptibility to this disease is located in or near the HLA complex. The objective of the present study was to investigate if a given HLA-A, B, or DR gene could represent a marker for susceptibility to essential hypertension at the population level. Thus, the frequencies of HLA antigens were determined in Caucasian patients with essential hypertension (HLA-A and B antigens were determined in 89 cases, 85 of which were also typed for HLA-DR antigens). The results showed an increased frequency (p = 0.00064) of HLA-DR4, which was present in 34% of the patients and in 16% of local ethnically matched control subjects. We conclude that HLA-DR4 may represent a marker for susceptibility to essential hypertension in the Brazilian Caucasian population.en
dc.description.affiliationUNIV SAO PAULO,HOSP CLIN,FAC MED,ESCOLA PAULISTA MED,SAO PAULO,BRAZIL
dc.description.affiliationUNIV SAO PAULO,HOSP CLIN,FAC MED,INST CORACAO,SAO PAULO,BRAZIL
dc.description.affiliationUnifespUNIV SAO PAULO,HOSP CLIN,FAC MED,ESCOLA PAULISTA MED,SAO PAULO,BRAZIL
dc.description.sourceWeb of Science
dc.format.extent400-402
dc.identifierhttps://doi.org/10.1161/01.HYP.19.4.400
dc.identifier.citationHypertension. Dallas: Amer Heart Assoc, v. 19, n. 4, p. 400-402, 1992.
dc.identifier.doi10.1161/01.HYP.19.4.400
dc.identifier.issn0194-911X
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/43817
dc.identifier.wosWOS:A1992HM35400016
dc.language.isoeng
dc.publisherAmer Heart Assoc
dc.relation.ispartofHypertension
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectESSENTIAL HYPERTENSIONen
dc.subjectHLA ANTIGENSen
dc.subjectIMMUNOGENETICSen
dc.subjectHISTOCOMPATIBILITY ANTIGENSen
dc.titleESSENTIAL-HYPERTENSION AND HISTOCOMPATIBILITY ANTIGENS - AN ASSOCIATION STUDYen
dc.typeinfo:eu-repo/semantics/article
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