A predictive score for retinopathy of prematurity in very low birth weight preterm infants

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dc.contributor.authorEckert, Gabriela Unchalo
dc.contributor.authorFortes Filho, Joao Borges
dc.contributor.authorMaia, Mauricio [UNIFESP]
dc.contributor.authorProcianoy, Renato Soibelmann
dc.contributor.institutionHosp Clin Porto Alegre
dc.contributor.institutionUniv Fed Rio Grande do Sul
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.date.accessioned2016-01-24T14:17:56Z
dc.date.available2016-01-24T14:17:56Z
dc.date.issued2012-03-01
dc.description.abstractAims This study describes the development of a score based on cumulative risk factors for the prediction of severe retinopathy of prematurity (ROP) comparing the performance of the score against the birth weight (BW) and gestational age (GA) in order to predict the onset of ROP.Methods A prospective cohort of preterm infants with BWp1500 g and/or GAp32 weeks was studied. the score was developed based on BW, GA, proportional weight gain from birth to the 6th week of life, use of oxygen in mechanical ventilation, and need for blood transfusions from birth to the 6th week of life. the score was established after linear regression, considering the impact of each variable on the occurrences of any stage and severe ROP. Receiver operating characteristic (ROC) curves were used to determine the best sensitivity and specificity values for the score. All variables were entered into an Excel spreadsheet (Microsoft) for practical use by ophthalmologists during screening sessions.Results the sample included 474 patients. the area under the ROC curve for the score was 0.77 and 0.88 to predict any stage and severe ROP, respectively. These values were significantly higher for the score than for BW (0.71) and GA (0.69) when measured separately.Conclusions ROPScore is an excellent index of neonatal risk factors for ROP, which is easy to record and more accurate than BW and GA to predict any stage ROP or severe ROP in preterm infants. the scoring system is simple enough to be routinely used by ophthalmologists during screening examination for detection of ROP. Eye (2012) 26, 400-406; doi: 10.1038/eye. 2011.334; published online 23 December 2011en
dc.description.affiliationHosp Clin Porto Alegre, Dept Ophthalmol, BR-90035903 Porto Alegre, RS, Brazil
dc.description.affiliationUniv Fed Rio Grande do Sul, Dept Ophthalmol, Sch Med, Porto Alegre, RS, Brazil
dc.description.affiliationUniversidade Federal de São Paulo, Dept Ophthalmol, Sch Med, São Paulo, Brazil
dc.description.affiliationUniv Fed Rio Grande do Sul, Dept Paediat, Newborn Sect, Sch Med, Porto Alegre, RS, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Dept Ophthalmol, Sch Med, São Paulo, Brazil
dc.description.sourceWeb of Science
dc.format.extent400-406
dc.identifierhttps://dx.doi.org/10.1038/eye.2011.334
dc.identifier.citationEye. London: Nature Publishing Group, v. 26, n. 3, p. 400-406, 2012.
dc.identifier.doi10.1038/eye.2011.334
dc.identifier.issn0950-222X
dc.identifier.urihttps://repositorio.unifesp.br/handle/11600/34638
dc.identifier.wosWOS:000301428900007
dc.language.isoeng
dc.publisherNature Publishing Group
dc.relation.ispartofEye
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectPrematurityen
dc.subjectRetinopathy of prematurityen
dc.subjectVery low birth weighten
dc.subjectRisk factorsen
dc.subjectSeverity illness scoreen
dc.titleA predictive score for retinopathy of prematurity in very low birth weight preterm infantsen
dc.typeinfo:eu-repo/semantics/article
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