Bone mineral density and vitamin D concentration: the challenges in taking care of children and adolescents infected with HIV

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dc.citation.issue3
dc.citation.volume21
dc.contributor.authorCarmo, Fabiana Bononi [UNIFESP]
dc.contributor.authorTerreri, Maria Teresa [UNIFESP]
dc.contributor.authorde Menezes Succi, Regina Celia [UNIFESP]
dc.contributor.authorBeltrao, Suenia Vasconcelos [UNIFESP]
dc.contributor.authorTome Barbosa Gouvea, Aida de Fatima [UNIFESP]
dc.contributor.authorCruz Paulino, Erica Regina [UNIFESP]
dc.contributor.authorMachado, Daisy Maria [UNIFESP]
dc.coverageRio De Janeiro
dc.date.accessioned2020-07-13T11:53:19Z
dc.date.available2020-07-13T11:53:19Z
dc.date.issued2017
dc.description.abstractBackground: The increase in life expectancy for patients living with human immunodeficiency virus (HIV) infection has resulted in health complications related to a chronic disease. Objectives: To evaluate the prevalence of bone mineral density (BMD) alterations and vitamin D concentrations in HIV-infected children and adolescents and to verify the variations in those parameters during a 12-month interval. Methods: A prospective cohort study with a dual period of evaluation was conducted in 57 patients perinatally HIV-infected and one patient with sexual abuse in early infancy. Demographic, anthropometric, pubertal stage, viral load, T CD4+ cell count and antiretroviral therapy were evaluated. Biochemical tests and total body (TB) and lumbar spine (L1-L4) bone density evaluations by dual X-ray absorptiometry (DXA) were performed. Calcium or vitamin D supplements were prescribed if reduction in BMD or deficiency for vitamin D was detected. Results: 58 patients (ages 5.4-18.3 yearsen
dc.description.abstract60.3% girls) were included (T0)en
dc.description.abstract55 patients were reevaluated after 12 (+/- 3) months (T1). Low bone mass for chronological age was found in 6/58 (10.4%) and 6/55(10.9%) patients at T0 and at T1, respectively. There was no statistical relationship between z-scores for BMD (BMD z-score) and the variables sex, fracture history, family history of osteoporosis, physical activity and pubertal stage. There was a relation between BMD z-score alterations for TB and HIV viral load at T1 (p = 0.016). There was no association between duration or classes of antiretroviral therapy and bone density. Themean value of vitamin D in T0 was 23.43 ng/mL +/- 2.015 and in T1 22.1ng/mL +/- 0.707 and considered insufficient levels for this population. Conclusion: Patients infected with HIV are at risk for BMD alterations and lower vitamin D serum concentrationsen
dc.description.abstractboth of these variables should be evaluated at routine examinations in order to improve both prevention and therapeutic planning. (C) 2017 Sociedade Brasileira de Infectologia. Published by Elsevier Editora Ltda.en
dc.description.affiliationUniv Fed Sao Paulo UNIFESP, Escola Paulista Med, Ctr Atendimento, Disciplina Infectol Pediat CEADIPe, Sao Paulo, SP, Brazil
dc.description.affiliationUniv Fed Sao Paulo UNIFESP, Escola Paulista Med, Setor Reumatol Pediat, Sao Paulo, SP, Brazil
dc.description.affiliationUnifespUniv Fed Sao Paulo UNIFESP, Escola Paulista Med, Ctr Atendimento, Disciplina Infectol Pediat CEADIPe, Sao Paulo, SP, Brazil
dc.description.affiliationUnifespUniv Fed Sao Paulo UNIFESP, Escola Paulista Med, Setor Reumatol Pediat, Sao Paulo, SP, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipFundacao de Auxilio a Pesquisa do Estado de Sao Paulo
dc.description.sponsorshipIDFAPESP: 2011/20882-2
dc.format.extent270-275
dc.identifierhttp://dx.doi.org/10.1016/j.bjid.2017.03.005
dc.identifier.citationBrazilian Journal Of Infectious Diseases. Rio De Janeiro, v. 21, n. 3, p. 270-275, 2017.
dc.identifier.doi10.1016/j.bjid.2017.03.005
dc.identifier.issn1413-8670
dc.identifier.urihttps://repositorio.unifesp.br/handle/11600/54538
dc.identifier.wosWOS:000404453600009
dc.language.isoeng
dc.publisherElsevier Brazil
dc.relation.ispartofBrazilian Journal Of Infectious Diseases
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectHIVen
dc.subjectAntiretroviralen
dc.subjectInfanten
dc.subjectDiagnosisen
dc.subjectMetabolismen
dc.subjectBoneaen
dc.titleBone mineral density and vitamin D concentration: the challenges in taking care of children and adolescents infected with HIVen
dc.typeinfo:eu-repo/semantics/article
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