Enterotype May Drive the Dietary-Associated Cardiometabolic Risk Factors

Página do item simplificado
dc.citation.volume7
dc.contributor.authorde Moraes, Ana C. F.
dc.contributor.authorFernandes, Gabriel R.
dc.contributor.authorda Silva, Isis T.
dc.contributor.authorAlmeida-Pititto, Bianca [UNIFESP]
dc.contributor.authorGomes, Everton P.
dc.contributor.authorPereira, Alexandre da Costa
dc.contributor.authorFerreira, Sandra R. G.
dc.coverageLausanne
dc.date.accessioned2020-07-17T14:02:56Z
dc.date.available2020-07-17T14:02:56Z
dc.date.issued2017
dc.description.abstractAnalyses of typical bacterial clusters in humans named enterotypes may facilitate understanding the host differences in the cardiometabolic profile. It stills unknown whether the three previously described enterotypes were present in populations living below the equator. We examined how the identification of enterotypes could be useful to explain the dietary associations with cardiometabolic risk factors in Brazilian subjects. In this cross-sectional study, a convenience sample of 268 adults (54.2% women) reported their dietary habits and had clinical and biological samples collected. In this study, we analyzed biochemical data and metagenomics of fecal microbiota (16SrRNA sequencing, V4 region). Continuous variables were compared using ANOVA, and categorical variables using chi-square test. Vsearch clustered the operational taxonomic units, and Silva Database provided the taxonomic signatures. Spearman coefficient was used to verify the correlation between bacteria abundances within each enterotype. One hundred subjects were classified as omnivore, 102 lacto-ovo-vegetarians, and 66 strict vegetarians. We found the same structure as the three previously described enterotypes: 111 participants were assigned to Bacteroides, 55 to Prevotella, and 102 to Ruminococcaceae enterotype. The Prevotella cluster contained higher amount of strict vegetarians individuals than the other enterotypes (40.0 vs. 20.7 and 20.6, p = 0.04). Subjects in this enterotype had a similar anthropometric profile but a lower mean LDL-c concentration than the Bacteroides enterotype (96 +/- 23 vs. 109 +/- 32 mg/dL, p = 0.04). We observed significant correlations between bacterial abundances and cardiometabolic risk factors, but coefficients differed depending on the enterotype. In Prevotella enterotype, Eubacterium ventriosum (r BMI = -0.33, p = 0.03, and r HDL-c = 0.33, p = 0.04), Akkermansia (r 2h glucose = -0.35, p = 0.02), Roseburia (r BMI = -0.36, p = 0.02 and r waist = -0.36, p = 0.02), and Faecalibacterium (r insulin = -0.35, p = 0.02) abundances were associated to better cardiometabolic profile. The three enterotypes previously described are present in Brazilians, supporting that those bacterial clusters are not population-specific. Diet-independent lower LDL-c levels in subjects from Prevotella than in other enterotypes suggest that a protective bacterial cluster in the former should be driving this association. Enterotypes seem to be useful to understand the impact of daily diet exposure on cardiometabolic risk factors. Prospective studies are needed to confirm their utility for predicting phenotypes in humans.en
dc.description.affiliationUniv Sao Paulo, Sch Publ Hlth, Dept Epidemiol, Sao Paulo, Brazil
dc.description.affiliationFundacao Oswaldo Cruz, Rene Rachou Res Ctr, Belo Horizonte, MG, Brazil
dc.description.affiliationUniv Fed Sao Paulo, Dept Prevent Med, Sao Paulo, Brazil
dc.description.affiliationUniv Sao Paulo, Sch Med, Heart Inst Incor, Lab Genet & Mol Cardiol, Sao Paulo, Brazil
dc.description.affiliationUnifespUniv Fed Sao Paulo, Dept Prevent Med, Sao Paulo, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipFAPESP
dc.description.sponsorshipIDFAPESP: 2012/12626-9
dc.description.sponsorshipIDFAPESP: 2012/03880-9
dc.format.extent-
dc.identifierhttp://dx.doi.org/10.3389/fcimb.2017.00047
dc.identifier.citationFrontiers In Cellular And Infection Microbiology. Lausanne, v. 7, p. -, 2017.
dc.identifier.doi10.3389/fcimb.2017.00047
dc.identifier.fileWOS000394551600002.pdf
dc.identifier.issn2235-2988
dc.identifier.urihttps://repositorio.unifesp.br/handle/11600/55095
dc.identifier.wosWOS:000394551600002
dc.language.isoeng
dc.publisherFrontiers Media Sa
dc.relation.ispartofFrontiers In Cellular And Infection Microbiology
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectgut microbiotaen
dc.subjectenterotypeen
dc.subjectcardiometabolic risken
dc.subjectdieten
dc.subjectlipid profileen
dc.titleEnterotype May Drive the Dietary-Associated Cardiometabolic Risk Factorsen
dc.typeinfo:eu-repo/semantics/article
Arquivos
Pacote Original
Agora exibindo 1 - 1 de 1
Imagem de Miniatura
Nome:
WOS000394551600002.pdf
Tamanho:
1.13 MB
Formato:
Adobe Portable Document Format
Descrição:
Baixar
Coleções
EPM - Artigos