Clinical Outcome of Intracytoplasmic Sperm Injection in Infertile Men With Treated and Untreated Clinical Varicocele

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dc.contributor.authorEsteves, Sandro C. [UNIFESP]
dc.contributor.authorOliveira, Fernanda V.
dc.contributor.authorBertolla, Ricardo P.
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.date.accessioned2016-01-24T14:05:31Z
dc.date.available2016-01-24T14:05:31Z
dc.date.issued2010-10-01
dc.description.abstractPurpose: We evaluated the impact of varicocelectomy on intracytoplasmic sperm injection outcomes in infertile men with clinical varicocele.Materials and Methods: We studied 242 infertile men with a history of clinical varicocele who underwent intracytoplasmic sperm injection. of the men 80 underwent prior subinguinal microsurgical varicocelectomy (treated group 1) and 162 had any grade of clinical varicocele (untreated group 2) at sperm injection. We compared semen analysis results before and after varicocelectomy, and the sperm injection procedure outcomes. Mean time from surgery to sperm injection was 6.2 months. Logistic regression was done to verify whether varicocelectomy influenced the odds of clinical pregnancy, live birth and miscarriage.Results: We noted an improved total number of motile sperm (6.7 x 10(6) vs 15.4 x 10(6), p < 0.01) and a decreased sperm defect score (2.2 vs 1.9, p = 0.01) after vs before varicocele repair. the clinical pregnancy (60.0% vs 45.0%, p = 0.04) and live birth (46.2% vs 31.4%, p = 0.03) rates after the sperm injection procedure were higher in the treated than in the untreated group. the chance of achieving clinical pregnancy (OR 1.82; 95% CI 1.06-3.15) and live birth (OR 1.87, 95% CI 1.08-3.25) by the sperm injection procedure were significantly increased while the chance of miscarriage was decreased (OR 0.433, 95% CI 0.22-0.84) after varicocele was treated.Conclusions: Results suggest that varicocelectomy improves clinical pregnancy and live birth rates by intracytoplasmic sperm injection in infertile couples in which the male partner has clinical varicocele. the chance of miscarriage may be decreased if varicocele is treated before assisted reproduction.en
dc.description.affiliationUniversidade Federal de São Paulo, ANDROFERT, Ctr Male Reprod, BR-13075460 São Paulo, Brazil
dc.description.affiliationUniversidade Federal de São Paulo, Dept Surg, Human Reprod Sect, Div Urol, BR-13075460 São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, ANDROFERT, Ctr Male Reprod, BR-13075460 São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Dept Surg, Human Reprod Sect, Div Urol, BR-13075460 São Paulo, Brazil
dc.description.sourceWeb of Science
dc.format.extent1442-1446
dc.identifierhttp://dx.doi.org/10.1016/j.juro.2010.06.004
dc.identifier.citationJournal of Urology. New York: Elsevier B.V., v. 184, n. 4, p. 1442-1446, 2010.
dc.identifier.doi10.1016/j.juro.2010.06.004
dc.identifier.issn0022-5347
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/32956
dc.identifier.wosWOS:000282615400080
dc.language.isoeng
dc.publisherElsevier B.V.
dc.relation.ispartofJournal of Urology
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.rights.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dc.subjecttestisen
dc.subjectinfertilityen
dc.subjectmaleen
dc.subjectsperm injectionsen
dc.subjectintracytoplasmicen
dc.subjectvaricoceleen
dc.subjectabortionen
dc.subjectspontaneousen
dc.titleClinical Outcome of Intracytoplasmic Sperm Injection in Infertile Men With Treated and Untreated Clinical Varicoceleen
dc.typeinfo:eu-repo/semantics/article
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