HUMAN PAPILLOMAVIRUS INFECTION IN PAPILLOMAS AND NONDISEASED RESPIRATORY SITES OF PATIENTS WITH RECURRENT RESPIRATORY PAPILLOMATOSIS USING THE POLYMERASE CHAIN-REACTION

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dc.contributor.authorSmith, Elaine M.
dc.contributor.authorPignatari, Shirley Shizue Nagata [UNIFESP]
dc.contributor.authorGray, Steven D.
dc.contributor.authorHaugen, Thomas H.
dc.contributor.authorTurek, Lubomir P.
dc.contributor.institutionUNIV IOWA
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.contributor.institutionUNIV UTAH
dc.contributor.institutionVET ADM MED CTR
dc.date.accessioned2018-06-15T13:56:02Z
dc.date.available2018-06-15T13:56:02Z
dc.date.issued1993-05-01
dc.description.abstractWe examined human papillomavirus (HPV) infection in biopsy specimens and cellular scrapes that were taken from respiratory papillomas and six nondiseased sites from the respiratory tract of seven patients. Human papillomavirus was detected by polymerase chain reaction amplification, followed by DNA hybridization with probes for specific HPV types. All papillomas (1 00.0%, n=5) were positive only for HPV type 6 or 11. In the nondiseased site specimens, 61.3% (19/31) of the specimens were positive, again only for HPV type 6 or 11. Among the nondiseased site specimens from the cervical trachea, intrathoracic trachea, and bronchus, 80% to 100% were HPV positive compared with only 25% to 50% of HPV infection detected in the nasopharynx, posterior tonsillar pillar, and aryepiglottic fold. These results support the tenet that HPV infection is present in clinically normal respiratory tract tissue and that the reservoir site of reinfection is more commonly in the lower airway. However, patients with upper-airway involvement were more likely to be diagnosed as having severe disease.en
dc.description.affiliationUNIV IOWA,COLL MED,DEPT PATHOL,IOWA CITY,IA 52242
dc.description.affiliationESCOLA PAULISTA MED,DEPT OFTALMOOTORRINOLARINGOL,DISCIPLINA OTORRINOLARINGOL,BR-04023 SAO PAULO,BRAZIL
dc.description.affiliationUNIV UTAH,MED CTR,COLL MED,DEPT SURG,DIV OTOLARYNGOL,SALT LAKE CITY,UT 84112
dc.description.affiliationVET ADM MED CTR,DEPT PATHOL,IOWA CITY,IA 52240
dc.description.affiliationUnifespESCOLA PAULISTA MED,DEPT OFTALMOOTORRINOLARINGOL,DISCIPLINA OTORRINOLARINGOL,BR-04023 SAO PAULO,BRAZIL
dc.description.sourceWeb of Science
dc.format.extent554-557
dc.identifierhttp://dx.doi.org/10.1001/archotol.1993.01880170080017
dc.identifier.citationArchives Of Otolaryngology-head & Neck Surgery. Chicago: Amer Medical Assoc, v. 119, n. 5, p. 554-557, 1993.
dc.identifier.doi10.1001/archotol.1993.01880170080017
dc.identifier.issn0886-4470
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/42662
dc.identifier.wosWOS:A1993LB51500016
dc.language.isoeng
dc.publisherAmer Medical Assoc
dc.relation.ispartofArchives Of Otolaryngology-head & Neck Surgery
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.titleHUMAN PAPILLOMAVIRUS INFECTION IN PAPILLOMAS AND NONDISEASED RESPIRATORY SITES OF PATIENTS WITH RECURRENT RESPIRATORY PAPILLOMATOSIS USING THE POLYMERASE CHAIN-REACTIONen
dc.typeinfo:eu-repo/semantics/article
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