Randomized study comparing the efficacy and tolerance of a lipohydroxy acid shampoo to a ciclopiroxolamine shampoo in the treatment of scalp seborrheic dermatitis

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dc.contributor.authorSeite, Sophie
dc.contributor.authorRougier, Andre
dc.contributor.authorTalarico, Sergio [UNIFESP]
dc.contributor.institutionLa Roche Posay Pharmaceut Labs
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.date.accessioned2016-01-24T13:58:59Z
dc.date.available2016-01-24T13:58:59Z
dc.date.issued2009-12-01
dc.description.abstractBackground the success of a dandruff treatment depends not only on the ability of a shampoo to control dandruff, but also on patient compliance, which is closely linked to the cosmetic attributes of the product.Aim the aim of this study was to compare efficacy, tolerance, and cosmetic properties of a LHA Shampoo [containing 0.1% lipohydroxy acid (LHA) and 1.3% salicylic acid] to a CPO shampoo [containing 1.5% ciclopiroxolamine (CPO), 3% salicylic acid, and 0.5% menthol] in subjects with seborrheic dermatitis (SD) of the scalp.Methods One hundred subjects with mild to moderate scalp SD were randomized to receive either the LHA shampoo or the CPO shampoo every 2 days for 4 weeks. Efficacy and tolerance were evaluated at days 0, 14, and 28.Results the LHA and the CPO shampoo both decreased symptoms of scale, erythema, itching, cutaneous discomfort, and dryness from baseline to day 28. A higher percentage of patients showed improvement in the group treated with the LHA formulation than in the group treated with the CPO formulation, but the difference did not reach statistical significance. At day 28, the tolerance and the global efficacy of the LHA shampoo were significantly better (P = 0.03 and P = 0.01, respectively) than those of the CPO shampoo. Furthermore, the cosmetic acceptability was better or significantly better for all the endpoints evaluated for the LHA shampoo (P = 0.02 for cleaning, P = 0.04 for lathering).Conclusion in conclusion, these results demonstrated that the lipohydroxy acid shampoo evaluated in this study is a more convenient, efficient, safe, and well-tolerated cosmetic treatment for mild-to-moderate seborrheic dermatitis of the scalp than a ciclopiroxolamine shampoo.en
dc.description.affiliationLa Roche Posay Pharmaceut Labs, F-92602 Asnieres, France
dc.description.affiliationUniversidade Federal de São Paulo, Escola Paulista Med, Dept Dermatol, São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Escola Paulista Med, Dept Dermatol, São Paulo, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipLa Roche-Posay Pharmaceutical Laboratories, Asnieres, France
dc.format.extent249-253
dc.identifierhttp://dx.doi.org/10.1111/j.1473-2165.2009.00460.x
dc.identifier.citationJournal of Cosmetic Dermatology. Malden: Wiley Periodicals, Inc, v. 8, n. 4, p. 249-253, 2009.
dc.identifier.doi10.1111/j.1473-2165.2009.00460.x
dc.identifier.issn1473-2130
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/32006
dc.identifier.wosWOS:000208137100003
dc.language.isoeng
dc.publisherWiley-Blackwell
dc.relation.ispartofJournal of Cosmetic Dermatology
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.rights.licensehttp://olabout.wiley.com/WileyCDA/Section/id-406071.html
dc.subjectdandruffen
dc.subjectseborrheic dermatitisen
dc.subjectlipohydroxy aciden
dc.subjectciclopiroxolamineen
dc.subjectshampooen
dc.subjectscalpen
dc.titleRandomized study comparing the efficacy and tolerance of a lipohydroxy acid shampoo to a ciclopiroxolamine shampoo in the treatment of scalp seborrheic dermatitisen
dc.typeinfo:eu-repo/semantics/article
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