Ultrasound-Promoted Synthesis of 3-(Thiophen-2-yl)-4,5-dihydro-1H-pyrazole-1carboximidamides and Anticancer Activity Evaluation in Leukemia Cell Lines

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dc.citation.issue2
dc.citation.volume28
dc.contributor.authordos Santos, Eric F. S.
dc.contributor.authorCury, Nathalia M.
dc.contributor.authordo Nascimento, Tainara A.
dc.contributor.authorRaminelli, Cristiano [UNIFESP]
dc.contributor.authorCasagrande, Gleison A.
dc.contributor.authorPereira, Claudio M. P.
dc.contributor.authorSimionatto, Euclesio
dc.contributor.authorYunes, Jose A.
dc.contributor.authorPizzuti, Lucas
dc.coverageSao Paulo
dc.date.accessioned2020-07-17T14:03:08Z
dc.date.available2020-07-17T14:03:08Z
dc.date.issued2017
dc.description.abstract3-(Thiophen-2-yl)-4,5-dihydro-1H-pyrazole-1-carboximidamides were efficiently prepared through a cyclocondensation of thiophenylchalcones with aminoguanidine hydrochloride under ultrasonic conditions in the presence of KOH and ethanol as a green solvent in short reaction times (15-35 min) and good yields (62-95%). All compounds produced were evaluated against the human Jurkat and RS4en
dc.description.abstract11 acute lymphoblastic leukemia cell lines of T- and B-cell origin, respectively, and the K562 myelogenous leukemia cell line. Six compounds presented half maximal inhibitory concentration (IC50) values around 15 mu mol L-1 and five compounds presented IC50 values around 40 mu mol L-1 for at least one of the three cell lines analyzed. One compound was not significantly cytotoxic, presenting IC50 value > 100 mu mol L- 1.en
dc.description.affiliationFundacao Univ Fed Grande Dourados, Grp Pesquisa Sintese & Caracterizacao Mol MS, Rua Joao Rosa Goes 1761, BR-79825070 Dourados, MS, Brazil
dc.description.affiliationUniv Estadual Campinas, Inst Biol, Dept Genet & Biol Mol, Rua Monteiro Lobato 255, BR-13083970 Campinas, SP, Brazil
dc.description.affiliationCtr Infantil Boldrini, Mol Biol Lab, Rua Dr Gabriel Porto 1270, BR-13083210 Campinas, SP, Brazil
dc.description.affiliationUniv Fed Sao Paulo, Dept Ciencias Exatas & Terra, Rua Prof Artur Riedel 275, BR-09972270 Diadema, SP, Brazil
dc.description.affiliationUniv Fed Pelotas, Ctr Ciencias Quim Farmaceut & Alimentos, Lab Lipid & Bioorgan, Campus Univ, BR-96001900 Pelotas, RS, Brazil
dc.description.affiliationUniv Estadual Mato Grosso do Sul, Rua Emilio Mascolli 275, BR-79950000 Navirai, MS, Brazil
dc.description.affiliationUnifespUniv Fed Sao Paulo, Dept Ciencias Exatas & Terra, Rua Prof Artur Riedel 275, BR-09972270 Diadema, SP, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipConselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPq)
dc.description.sponsorshipFundacao de Apoio ao Desenvolvimento do Ensino, Ciencia e Tecnologia do Estado de Mato Grosso do Sul (FUNDECT)
dc.description.sponsorshipFundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP)
dc.description.sponsorshipCoordenacao de Aperfeicoamento de Pessoal de Nivel Superior (CAPES)
dc.description.sponsorshipFAPESP
dc.description.sponsorshipCNPq
dc.description.sponsorshipIDCNPq: 483021/2013-0
dc.description.sponsorshipIDFUNDECT: 0180/12
dc.description.sponsorshipIDFAPESP: 12/12802-1
dc.format.extent217-224
dc.identifierhttp://dx.doi.org/10.5935/0103-5053.20160166
dc.identifier.citationJournal Of The Brazilian Chemical Society. Sao Paulo, v. 28, n. 2, p. 217-224 2017.
dc.identifier.doi10.5935/0103-5053.20160166
dc.identifier.fileWOS000394031600003.pdf
dc.identifier.issn0103-5053
dc.identifier.urihttps://repositorio.unifesp.br/handle/11600/55181
dc.identifier.wosWOS:000394031600003
dc.language.isoeng
dc.publisherSoc Brasileira Quimica
dc.relation.ispartofJournal Of The Brazilian Chemical Society
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectamidinopyrazoleen
dc.subjectpyrazolineen
dc.subjectcytotoxic activityen
dc.subjectleukemiaen
dc.subjectultrasonic irradiationen
dc.titleUltrasound-Promoted Synthesis of 3-(Thiophen-2-yl)-4,5-dihydro-1H-pyrazole-1carboximidamides and Anticancer Activity Evaluation in Leukemia Cell Linesen
dc.typeinfo:eu-repo/semantics/article
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