Selectivity of human T lymphotropic virus type-1 (HTLV-1) and HTLV-2 infection among different populations in Brazil

dc.contributor.authorGabbai, Alberto Alain [UNIFESP]
dc.contributor.authorBordin, Jose Orlando [UNIFESP]
dc.contributor.authorVieira Filho, João Paulo Botelho [UNIFESP]
dc.contributor.authorKuroda, Akemi [UNIFESP]
dc.contributor.authorOliveira, Acary Souza Bulle [UNIFESP]
dc.contributor.authorCruz, M. V.
dc.contributor.authorRibeiro, AAF
dc.contributor.authorDelaney, SR
dc.contributor.authorHenrard, D. R.
dc.contributor.authorRosario, J.
dc.contributor.authorRoman, G. C.
dc.contributor.institutionABBOTT LABS
dc.contributor.institutionNINCDS
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.date.accessioned2018-06-15T13:45:59Z
dc.date.available2018-06-15T13:45:59Z
dc.date.issued1993-12-01
dc.description.abstractA seroprevalence study for human T lymphotropic virus type-I (HTLV-1) and HTLV-2 was conducted in Sao Paulo, Brazil among 2,312 individuals that included following groups: 1, 148 volunteer blood donors, 3 7 patients with tropical spastic paraparcsis (TSP), 53 with lymphoproliferative disorders, 171 with a history of multiple blood transfusions, 268 human immunodeficiency virus type-1 (HIV- 1) seropositive subjects, and 635 Amazonian Indians. Antibodies to HTLV-1/2 were screened by enzyme-linked immunosorbent assay (ELISA) and confirmed by Western blot and/or radioimmunoprecipitation. The differentiation of HTLV-1 and HTLV-2 was achieved using a synthetic recombinant peptide (rgp46) ELISA. We confirmed the presence of HTLV-1 infection in Brazil, both in blood donors (0.4%) and in patients exposed to blood transfusions (2.9%), as well as the occurrence of HTLV-I-associated TSP (11 patients, or 30% of all TSP cases) and adult T cell leukemia/lymphoma (two cases, or 3.5% of all hematologic malignancies). The HIV-1 infected individuals were shown to be coinfected (8.9%) with either HTLV-1 or HTLV-2. All HIV-1 and HTLV-2 coinfected individuals were intravenous drug abusers. In addition, we also demonstrated the presence of HTLV-2 (4.7%), and HTLV-1/2 (0.8%) in tribes of Amazonian Indians who lived in the eastern Amazon basin (southeastern State of Para). The selectivity of these retroviral infections in particular groups is emphasized, as well as the need for HTLV-1/2 screening of all blood donors in Brazil as a public health measure.en
dc.description.affiliationABBOTT LABS,N CHICAGO,IL 60064
dc.description.affiliationNINCDS,NEUROEPIDEMIOL BRANCH,BETHESDA,MD 20892
dc.description.sourceWeb of Science
dc.format.extent664-671
dc.identifierhttps://doi.org/10.4269/ajtmh.1993.49.664
dc.identifier.citationAmerican Journal Of Tropical Medicine And Hygiene. Mclean: Amer Soc Trop Med & Hygiene, v. 49, n. 6, p. 664-671, 1993.
dc.identifier.doi10.4269/ajtmh.1993.49.664
dc.identifier.issn0002-9637
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/42470
dc.identifier.wosWOS:A1993MR26100002
dc.language.isoeng
dc.publisherAmer Soc Trop Med & Hygiene
dc.relation.ispartofAmerican Journal Of Tropical Medicine And Hygiene
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.titleSelectivity of human T lymphotropic virus type-1 (HTLV-1) and HTLV-2 infection among different populations in Brazilen
dc.typeinfo:eu-repo/semantics/article
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