Effects of reversible inactivation of the dorsomedial hypothalamus on panic- and anxiety-related responses in rats

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dc.contributor.authorNascimento, Juliana Olivetti Guzman [UNIFESP]
dc.contributor.authorZangrossi Junior, Helio
dc.contributor.authorViana, Milena de Barros [UNIFESP]
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.date.accessioned2015-06-14T13:41:52Z
dc.date.available2015-06-14T13:41:52Z
dc.date.issued2010-09-01
dc.description.abstractThe medial hypothalamus is part of a neurobiological substrate controlling defensive behavior. It has been shown that a hypothalamic nucleus, the dorsomedial hypothalamus (DMH), is involved in the regulation of escape, a defensive behavior related to panic attacks. The role played by the DMH in the organization of conditioned fear responses, however, is less clear. In the present study, we investigated the effects of reversible inactivation of the DMH with the GABA A agonist muscimol on inhibitory avoidance acquisition and escape expression by male Wistar rats (approximately 280 g in weight) tested in the elevated T-maze (ETM). In the ETM, inhibitory avoidance, a conditioned defensive response, has been associated with generalized anxiety disorder. Results showed that intra-DMH administration of the GABA A receptor agonist muscimol inhibited escape performance, suggesting an antipanic-like effect (P < 0.05), without changing inhibitory avoidance acquisition. Although a higher dose of muscimol (1.0 nmol/0.2 µL; N = 7) also altered locomotor activity in an open field when compared to control animals (0.2 µL saline; N = 13) (P < 0.05), the lower dose (0.5 nmol/0.2 µL; N = 12) of muscimol did not cause any motor impairment. These data corroborate previous evidence suggesting that the DMH is specifically involved in the modulation of escape. Dysfunction of this regulatory mechanism may be relevant in the genesis/maintenance of panic disorder.en
dc.description.affiliationUniversidade Federal de São Paulo (UNIFESP) Departamento de Psiquiatria
dc.description.affiliationUniversidade de São Paulo Faculdade de Medicina de Ribeirao Preto Departamento de Farmacologia
dc.description.affiliationUniversidade Federal de São Paulo (UNIFESP) Departamento de Biociências
dc.description.affiliationUnifespUNIFESP, Depto. de Psiquiatria
dc.description.affiliationUnifespUNIFESP, Depto. de Biociências
dc.description.sourceSciELO
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.format.extent869-873
dc.identifierhttps://dx.doi.org/10.1590/S0100-879X2010007500075
dc.identifier.citationBrazilian Journal of Medical and Biological Research. Associação Brasileira de Divulgação Científica, v. 43, n. 9, p. 869-873, 2010.
dc.identifier.doi10.1590/S0100-879X2010007500075
dc.identifier.fileS0100-879X2010000900009.pdf
dc.identifier.issn0100-879X
dc.identifier.scieloS0100-879X2010000900009
dc.identifier.urihttps://repositorio.unifesp.br/handle/11600/5921
dc.identifier.wosWOS:000283262800009
dc.language.isoeng
dc.publisherAssociação Brasileira de Divulgação Científica
dc.relation.ispartofBrazilian Journal of Medical and Biological Research
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectMuscimolen
dc.subjectGeneralized anxiety disorderen
dc.subjectPanic disorderen
dc.subjectDorsomedial hypothalamusen
dc.subjectElevated T-mazeen
dc.titleEffects of reversible inactivation of the dorsomedial hypothalamus on panic- and anxiety-related responses in ratsen
dc.typeinfo:eu-repo/semantics/article
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