The Use of Botulinum Toxin to Treat Infantile Esotropia: A Systematic Review With Meta-Analysis

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dc.citation.issue12
dc.citation.volume58
dc.contributor.authorIssaho, Dayane Cristine [UNIFESP]
dc.contributor.authorde Souza Carvalho, Fabio Ramos [UNIFESP]
dc.contributor.authorUyeno Tabuse, Marcia Keiko [UNIFESP]
dc.contributor.authorCarrijo-Carvalho, Linda Christian [UNIFESP]
dc.contributor.authorde Freitas, Denise [UNIFESP]
dc.coverageRockville
dc.date.accessioned2020-08-04T13:40:06Z
dc.date.available2020-08-04T13:40:06Z
dc.date.issued2017
dc.description.abstractPURPOSE. The purpose of this review was to examine the efficacy of botulinum toxin in the treatment of infantile esotropia and to evaluate the average response of BT and its complication rates. METHODS. A research was performed in the Latin American and Caribbean Literature on Health Sciences (LILACS), MEDLINE, and Cochrane Central Register of Controlled Trial (CENTRAL). The database was searched between December 28, 2016 and January 30, 2017. The selection was restricted to articles published in English, Spanish, or Portuguese. There were no date restrictions in the search. RESUITS. Nine studies were eligible for inclusion. The grouped success rate of BT treatment in infantile esotropia was 76% (95% confidence interval [CI]: 61%-89%). For the success rate, 1 2 of 94.25% was observed, indicating a high heterogeneity (P < 0.001). The complication rates were also analyzed. The grouped consecutive exotropia (X'F) rate was 1% (95% CI: 0%-2%). The grouped ptosis rate was 27% (95% CI: 21%-33%). The grouped vertical deviation rate was 12% (95% CI: 4%-22%). The mean change of the deviation after BT injection was -30.7 (95% CI: -37.7, -23.8), demonstrating a significant improvement in alignment. CONCLUSIONS. Botulinum toxin injection into medial recti muscles reveals to be a safe procedure and a valuable alternative to strabismus surgery in congenital esotropia, especially in moderate deviations.en
dc.description.affiliationHosp Olhos Parana, Coronel Dulcidio,199,1 Andar, BR-80420170 Curitiba, PR, Brazil
dc.description.affiliationUniv Fed Sao Paulo, Ophthalmol & Visual Sci, Sao Paulo, Brazil
dc.description.affiliationUnifespUniv Fed Sao Paulo, Ophthalmol & Visual Sci, Sao Paulo, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipSao Paulo Research Foundation (FAPESP), Ministry of Education of Brazil
dc.description.sponsorshipCoordination for the Improvement of Higher Education Personnel (CAPES), Ministry of Education of Brazil
dc.description.sponsorshipNational Council for Scientific and Technological Development
dc.description.sponsorshipIDFAPESP: 2011/51626-1
dc.description.sponsorshipIDFAPESP: 2012/15603-0
dc.format.extent5468-5476
dc.identifierhttp://dx.doi.org/10.1167/iovs.17-22576
dc.identifier.citationInvestigative Ophthalmology & Visual Science. Rockville, v. 58, n. 12, p. 5468-5476, 2017.
dc.identifier.doi10.1167/iovs.17-22576
dc.identifier.fileWOS000414272100050.pdf
dc.identifier.issn0146-0404
dc.identifier.urihttps://repositorio.unifesp.br/handle/11600/57287
dc.identifier.wosWOS:000414272100050
dc.language.isoeng
dc.publisherAssoc Research Vision Ophthalmology Inc
dc.relation.ispartofInvestigative Ophthalmology & Visual Science
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectbotulinum toxinen
dc.subjectstrabismusen
dc.subjectinfantile esotropiaen
dc.titleThe Use of Botulinum Toxin to Treat Infantile Esotropia: A Systematic Review With Meta-Analysisen
dc.typeinfo:eu-repo/semantics/article
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