INTRAVITREAL BEVACIZUMAB FOR CHOROIDAL NEOVASCULARIZATION IN AGE-RELATED MACULAR DEGENERATION 5-Year Results of The Pan-American Collaborative Retina Study Group

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dc.citation.issue5
dc.citation.volume36
dc.contributor.authorArevalo, J. Fernando
dc.contributor.authorLasave, Andres F.
dc.contributor.authorWu, Lihteh
dc.contributor.authorAcon, Dhariana
dc.contributor.authorBerrocal, Maria H.
dc.contributor.authorDiaz-Llopis, Manuel
dc.contributor.authorGallego-Pinazo, Roberto
dc.contributor.authorSerrano, Martin A.
dc.contributor.authorAlezzandrini, Arturo A.
dc.contributor.authorRojas, Sergio
dc.contributor.authorMaia, Mauricio [UNIFESP]
dc.contributor.authorLujan, Silvio
dc.coveragePhiladelphia
dc.date.accessioned2020-07-22T13:23:02Z
dc.date.available2020-07-22T13:23:02Z
dc.date.issued2016
dc.description.abstractPurpose: To report the long-term anatomical and functional outcomes of patients with choroidal neovascularization secondary to age-related macular degeneration treated with intravitreal bevacizumab (IVB). Methods: Retrospective case series. Patients diagnosed with subfoveal choroidal neovascularization secondary to age-related macular degeneration that were treated with at least 1 intravitreal injection of 1.25 mg of IVB and had a minimum follow-up of 60 months. Patients underwent best-corrected Snellen visual acuity testing, optical coherence tomography, and ophthalmoscopic examination at baseline and follow-up visits. Results: Two hundred and forty-seven consecutive patients (292 eyes) were included. The mean number of IVB injections per eye was 10.9 +/- 6.4. At 5 years, the BCVA decreased from 20/150 (logMAR 0.9 +/- 0.6) at baseline to 20/250 (logMAR 1.1 +/- 0.7) (P = <0.0001). The mean CMT decreased from 343.1+ 122.3 mm at baseline to 314.7 +/- 128.8 mm at 60 months of follow-up (P = 0.009). Geographic atrophy (GA) was observed at baseline in 47 (16%) of 292 eyes. By 5 years, GA developed or progressed in 124 (42.5%) of 292 eyes (P < 0.0001). Conclusion: The early visual gains obtained from IVB were not maintained at 5 years of follow-up. In addition, IVB may play a role in the development or progression of GA.en
dc.description.affiliationJohns Hopkins Univ, Sch Med, Wilmer Eye Inst, Retina Div, Baltimore, MD 21287 USA
dc.description.affiliationKing Khalid Eye Specialist Hosp, Vitreoretinal & Uveitis Div, Riyadh, Saudi Arabia
dc.description.affiliationClin Privada Ojos, Retina & Vitreous Serv, Mar Del Plata, Buenos Aires, Argentina
dc.description.affiliationInst Cirugia Ocular, San Jose, Costa Rica
dc.description.affiliationUniv Puerto Rico, San Juan, PR 00936 USA
dc.description.affiliationUniv Valencia, Hosp La Fe, E-46003 Valencia, Spain
dc.description.affiliationCtr Caracas, Clin Oftalmol, Caracas, Venezuela
dc.description.affiliationArevalo Coutinho Fdn Res Ophthalmol, Caracas, Venezuela
dc.description.affiliationUniv Buenos Aires, Fac Med, OFTALMOS, Buenos Aires, DF, Argentina
dc.description.affiliationFundac Hosp Nuestra Senora Luz, Mexico City, DF, Mexico
dc.description.affiliationFed Univ Sao Paulo UNIFESP, Dept Ophthalmol & Visual Sci, Retina Div, Sao Paulo, Brazil
dc.description.affiliationMACULA D&T Diagnst, Tratamiento & Rehabil Visual, Lima, Peru
dc.description.affiliationUnifespFed Univ Sao Paulo UNIFESP, Dept Ophthalmol & Visual Sci, Retina Div, Sao Paulo, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipSECOND SIGHT LLC
dc.description.sponsorshipSpringer SBM LLC
dc.description.sponsorshipALCON LABORATORIES
dc.description.sponsorshipEyEngineering Inc
dc.description.sponsorshipDORC International B.V.
dc.description.sponsorshipBayer AG
dc.format.extent859-867
dc.identifierhttp://dx.doi.org/10.1097/IAE.0000000000000827
dc.identifier.citationRetina-The Journal Of Retinal And Vitreous Diseases. Philadelphia, v. 36, n. 5, p. 859-867, 2016.
dc.identifier.doi10.1097/IAE.0000000000000827
dc.identifier.issn0275-004X
dc.identifier.urihttps://repositorio.unifesp.br/handle/11600/55993
dc.identifier.wosWOS:000375482100009
dc.language.isoeng
dc.publisherLippincott Williams & Wilkins
dc.relation.ispartofRetina-The Journal Of Retinal And Vitreous Diseases
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.subjectaflibercepten
dc.subjectbevacizumaben
dc.subjectchoroidal neovascularizationen
dc.subjectranibizumaben
dc.subjectvascular endothelial growth factoren
dc.titleINTRAVITREAL BEVACIZUMAB FOR CHOROIDAL NEOVASCULARIZATION IN AGE-RELATED MACULAR DEGENERATION 5-Year Results of The Pan-American Collaborative Retina Study Groupen
dc.typeinfo:eu-repo/semantics/article
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