Futura study: evaluation of efficacy and safety of rupatadine fumarate in the treatment of persistent allergic rhinitis

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dc.contributor.authorMion, Olavo de Godoy
dc.contributor.authorCampos, Regis A.
dc.contributor.authorAntila, Martti
dc.contributor.authorRapoport, Priscila Bogar
dc.contributor.authorRosario Filho, Nelson Augusto
dc.contributor.authorMello Júnior, João Ferreira de
dc.contributor.authorGuimarães, Roberto Eustáquio Santos
dc.contributor.authorMocellin, Marcos
dc.contributor.authorDi Gesu, Giovanni
dc.contributor.authorSolé, Dirceu [UNIFESP]
dc.contributor.authorWexler, Luc [UNIFESP]
dc.contributor.authorMello, João Ferreira de [UNIFESP]
dc.contributor.authorCastro, Fábio Fernandes Morato
dc.contributor.authorChavarria, Maria Letícia
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.contributor.institutionYale University School of Medicine Allergy Department
dc.contributor.institutionFederal University of Bahia Medical School
dc.contributor.institutionASBAI
dc.contributor.institutionOphthalmology Hospital Department ENT
dc.contributor.institutionMedical School
dc.contributor.institutionFederal University of Paraná
dc.contributor.institutionUniversity of São Paulo Medical School
dc.contributor.institutionFederal University of Minas Gerais Medical School Department of Otorhinolaryngology and Ophthalmology
dc.contributor.institutionFederal University of Paraná ENT Department
dc.contributor.institutionSanta Casa de Porto Alegre Hospital Santo Antônio Children Hospital Allergy Department
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.contributor.institutionState Public Servant Hospital Allergy Department
dc.contributor.institutionUFG
dc.date.accessioned2015-06-14T13:41:13Z
dc.date.available2015-06-14T13:41:13Z
dc.date.issued2009-10-01
dc.description.abstractAllergic rhinitis affects 10-30% of the population, negatively impacting one's quality of life and productivity. It has been associated with sinusitis, otitis media, sleep disorders, and asthma. Rupatadine is a second generation antihistamine with increased affinity to histamine receptor H1; it is also a potent PAF (platelet-activating factor) antagonist. It starts acting quite quickly, offers long lasting effect, and reduces the chronic effects of rhinitis. AIM: this study aims to assess the efficacy and safety of rupatadine in the treatment of persistent allergic rhinitis. MATERIALS AND METHOD: this is a multi-centric open prospective study. This study included 241 patients from 13 centers in Brazil and was held between October of 2004 and August of 2005. Signs and symptoms of rhinitis and tolerance to medication were analyzed after one and two weeks of treatment. RESULTS: reduction on general scores from 8.65 to 3.21 on week 2 (p<0.001). All signs and symptoms improved significantly in the first day of treatment (p<0.001), except for nasal congestion and secretion, which improved from the second day of treatment (p<0.001). Adverse events occurred in 19.9% of the cases, 27.7% on week 1. CONCLUSION: rupatadine effectively controls persistent allergic rhinitis; it is safe and presents low incidence of side effects.en
dc.description.abstractA rinite alérgica acomete 10 a 30% da população, interferindo na qualidade de vida e na capacidade produtiva. Está associada à sinusite, otite, roncopatias e asma. A Rupatadina é um anti-histamínico de segunda geração, com elevada afinidade ao receptor histamínico H1 e potente inibição do fator ativador plaquetário (PAF). Tem rápido início de ação, longa duração e reduz os efeitos crônicos da rinite. OBJETIVO: Avaliar a eficácia e segurança da rupatadina no tratamento da rinite alérgica persistente. MATERIAL E MÉTODO: Estudo multicêntrico, aberto, prospectivo. Foram selecionados 241 pacientes em 13 centros no Brasil durante o período de outubro de 2004 a agosto de 2005. Foram analisados os sinais e sintomas da rinite e a tolerabilidade após 1 e 2 semanas. RESULTADOS: Redução do escore geral de 8,65 para 3,21 na semana 2 (p<0,001). Todos os sinais e sintomas melhoraram significativamente, e no primeiro dia de tratamento (p<0,001), com exceção da obstrução e secreção nasal, a partir do segundo dia (P<0,001). A frequência de eventos adversos foi 19,9%, sendo 27,7% na 1ª semana. CONCLUSÕES: A rupatadina é eficaz no controle da rinite alérgica persistente, é segura e apresenta baixos índices de efeitos colaterais.pt
dc.description.affiliationUSP
dc.description.affiliationYale University School of Medicine Allergy Department
dc.description.affiliationFederal University of Bahia Medical School
dc.description.affiliationASBAI
dc.description.affiliationOphthalmology Hospital Department ENT
dc.description.affiliationMedical School
dc.description.affiliationFederal University of Paraná
dc.description.affiliationUniversity of São Paulo Medical School
dc.description.affiliationFederal University of Minas Gerais Medical School Department of Otorhinolaryngology and Ophthalmology
dc.description.affiliationFederal University of Paraná ENT Department
dc.description.affiliationSanta Casa de Porto Alegre Hospital Santo Antônio Children Hospital Allergy Department
dc.description.affiliationUniversidade Federal de São Paulo (UNIFESP), Escola Paulista de Medicina (EPM) Department of Pediatrics
dc.description.affiliationUNIFESP
dc.description.affiliationState Public Servant Hospital Allergy Department
dc.description.affiliationUFG
dc.description.affiliationUnifespUNIFESP, EPM, Department of Pediatrics
dc.description.affiliationUnifespUNIFESP
dc.description.sourceSciELO
dc.format.extent673-679
dc.identifierhttp://dx.doi.org/10.1590/S1808-86942009000500011
dc.identifier.citationBrazilian Journal of Otorhinolaryngology. Associação Brasileira de Otorrinolaringologia e Cirurgia Cervicofacial, v. 75, n. 5, p. 673-679, 2009.
dc.identifier.doi10.1590/S1808-86942009000500011
dc.identifier.fileS1808-86942009000500011.pdf
dc.identifier.issn1808-8694
dc.identifier.scieloS1808-86942009000500011
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/5294
dc.language.isoeng
dc.publisherAssociação Brasileira de Otorrinolaringologia e Cirurgia Cervicofacial
dc.relation.ispartofBrazilian Journal of Otorhinolaryngology
dc.rightsAcesso aberto
dc.subjectperennial allergic rhinitisen
dc.subjecttherapyen
dc.subjectrinite alérgica perenept
dc.subjectterapiapt
dc.titleFutura study: evaluation of efficacy and safety of rupatadine fumarate in the treatment of persistent allergic rhinitisen
dc.title.alternativeEstudo futura: avaliação da eficácia e segurança do fumarato de rupatadina no tratamento da rinite alérgica persistentept
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