Histomorphometric Analysis and Markers of Endometrial Receptivity Embryonic Implantation in Women With Polycystic Ovary Syndrome During the Treatment With Progesterone

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dc.contributor.authorRibeiro Soares Lopes, Ione Maria
dc.contributor.authorMaganhin, Carla Cristina [UNIFESP]
dc.contributor.authorOliveira-Filho, Ricardo Martins
dc.contributor.authorSimoes, Ricardo Santos
dc.contributor.authorSimoes, Manuel Jesus [UNIFESP]
dc.contributor.authorIwata, Margareth Chiharu [UNIFESP]
dc.contributor.authorBaracat, Edmund Chada
dc.contributor.authorSoares, Jose Maria [UNIFESP]
dc.contributor.institutionUniv Fed Piaui
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.date.accessioned2016-01-24T14:37:34Z
dc.date.available2016-01-24T14:37:34Z
dc.date.issued2014-07-01
dc.description.abstractLiterature data indicate that the infertility in women with polycystic ovary syndrome (PCOS) is not only attributed to anovulation but also to endometrial dysfunction. Endometrial biopsies were performed in the proliferative and secretory phases of women with normal cycle and in women with PCOS before and after oral treatment with micronized progesterone. After the treatment, the endometrium of the women with PCOS exhibited a lower number of glands and thicker luminal epithelium compared to the normal women in the secretory phase. in addition, the PCOS group exhibited reduced integrin and MECA-79 immunoexpression during the secretory phase. the expression of E-cadherin was higher in the PCOS and the expression of intercellular adhesion molecule 1 was lower in PCOS, during the secretory and proliferative phases, respectively. Also, there is a negative correlation with MECA-79 and integrin expression and body mass index. Conventional doses of progesterone may not be enough to correct the changes of endometrial histomorphology and the receptive markers of PCOS-bearing women. the obesity may be a factor that interferes with this response.en
dc.description.affiliationUniv Fed Piaui, UFPI, Dept Materno Infantil, Ctr Ciencias Saude, Teresina, Brazil
dc.description.affiliationUniversidade Federal de São Paulo, EPM UNIFESP, Escola Paulista Med, Dept Ginecol, São Paulo, Brazil
dc.description.affiliationUniv São Paulo, Inst Ciencias Biomed, Dept Farmacol, BR-05508 São Paulo, Brazil
dc.description.affiliationUniv São Paulo, Fac Med, Dept Obstet & Ginecol, Disciplina Ginecol, São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, EPM UNIFESP, Escola Paulista Med, Dept Ginecol, São Paulo, Brazil
dc.description.sourceWeb of Science
dc.format.extent930-938
dc.identifierhttp://dx.doi.org/10.1177/1933719113519169
dc.identifier.citationReproductive Sciences. Thousand Oaks: Sage Publications Inc, v. 21, n. 7, p. 930-938, 2014.
dc.identifier.doi10.1177/1933719113519169
dc.identifier.issn1933-7191
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/37978
dc.identifier.wosWOS:000340200300013
dc.language.isoeng
dc.publisherSage Publications Inc
dc.relation.ispartofReproductive Sciences
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.rights.licensehttp://www.uk.sagepub.com/aboutus/openaccess.htm
dc.subjectpolycystic ovary syndromeen
dc.subjectendometriumen
dc.subjectcell adhesion moleculesen
dc.titleHistomorphometric Analysis and Markers of Endometrial Receptivity Embryonic Implantation in Women With Polycystic Ovary Syndrome During the Treatment With Progesteroneen
dc.typeinfo:eu-repo/semantics/article
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