Relationships between adiponectin levels, the metabolic syndrome, and type 2 diabetes: a literature review

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dc.citation.issue6
dc.citation.volume61
dc.contributor.authorvon Frankenberg, Anize Delfino
dc.contributor.authorReis, Andre F. [UNIFESP]
dc.contributor.authorGerchman, Fernando
dc.coverageRio De Janeiro, Rj
dc.date.accessioned2020-07-02T18:52:21Z
dc.date.available2020-07-02T18:52:21Z
dc.date.issued2017
dc.description.abstractElevated hepatic glucose production, impaired insulin secretion, and insulin resistance - abnormalities of glucose metabolism typically found in subjects with obesity - are major factors underlying the pathogenesis of type 2 diabetes (DM2) and the metabolic syndrome (MS). Adiponectin is a major regulator of glucose and lipid homeostasis via its insulin-sensitizing properties, and lower levels seems to be associated with the development of DM2 and MS. The purpose of this review is to clarify the mechanisms whereby adiponectin relates to the development of DM2 and MS and the association between polymorphisms of the adiponectin gene, circulating levels of the hormone, and its relationships with DM2. In addition, the impact of dietary lipids in the circulating levels of adiponectin will be addressed. According to the literature, circulating adiponectin levels seem to decrease as the number of MS components increases. Lower adiponectin concentrations are associated with higher intra-abdominal fat content. Therefore, adiponectin could link intra-abdominal fat with insulin resistance and development of MS. Therapeutic strategies that target the MS and its components, such as lifestyle modification through physical activity and weight loss, have been shown to increase adiponectin concentrations. Possible roles of diets containing either low or high amounts of fat, or different types of fat, have been analyzed in several studies, with heterogeneous results. Supplementation with n-3 PUFA modestly increases adiponectin levels, whereas conjugated linoleic acid supplementation appears to reduce concentrations when compared with unsaturated fatty acid supplementation used as an active placebo.en
dc.description.affiliationUniv Fed Rio Grande do Sul, Fac Med, Programa Posgrad Endocrinol, Porto Alegre, RS, Brazil
dc.description.affiliationUFCSPA, Dept Nutr, Porto Alegre, RS, Brazil
dc.description.affiliationUniv Fed Sao Paulo Unifesp, Dept Med, Disciplina Endocrinol, Sao Paulo, SP, Brazil
dc.description.affiliationHCPA, Div Endocrinol, Unidade Metab, Porto Alegre, RS, Brazil
dc.description.affiliationUnifespUniv Fed Sao Paulo Unifesp, Dept Med, Disciplina Endocrinol, Sao Paulo, SP, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipState of Rio Grande do Sul Foundation for Research Support [Fapergs PG 5989.284.18921.12062013]
dc.description.sponsorshipHospital de Clinicas de Porto Alegre Research and Event Incentive Fund [FIPE-HCPA 11-226]
dc.description.sponsorshipBrazilian National Research Council [CNPq 486802/2013-2]
dc.description.sponsorshipID[Fapergs PG 5989.284.18921.12062013]
dc.description.sponsorshipIDHospital de Clinicas de Porto Alegre Research and Event Incentive Fund [FIPE-HCPA 11-226]
dc.description.sponsorshipID[CNPq 486802/2013-2]
dc.format.extent614-622
dc.identifierhttp://dx.doi.org/10.1590/2359-3997000000316
dc.identifier.citationArchives Of Endocrinology Metabolism. Rio De Janeiro, Rj, v. 61, n. 6, p. 614-622, 2017.
dc.identifier.doi10.1590/2359-3997000000316
dc.identifier.fileWOS000424375800016.pdf
dc.identifier.issn2359-3997
dc.identifier.urihttps://repositorio.unifesp.br/handle/11600/54019
dc.identifier.wosWOS:000424375800016
dc.language.isoeng
dc.publisherSbem-Soc Brasil Endocrinologia & Metabologia
dc.relation.ispartofArchives Of Endocrinology Metabolism
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectAdiponectinen
dc.subjectmetabolic syndromeen
dc.subjecttype 2 diabetesen
dc.titleRelationships between adiponectin levels, the metabolic syndrome, and type 2 diabetes: a literature reviewen
dc.typeinfo:eu-repo/semantics/article
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