Atypical antipsychotic olanzapine reversed deficit on prepulse inhibition of the acoustic startle reflex produced by microinjection of dizocilpine (MK-801) into the inferior colliculus in rats

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dc.contributor.authorZangrando, Julia [UNIFESP]
dc.contributor.authorCarvalheira, Renata [UNIFESP]
dc.contributor.authorLabbate, Giovanna Puosso [UNIFESP]
dc.contributor.authorMedeiros, Priscila [UNIFESP]
dc.contributor.authorLongo, Beatriz Monteiro [UNIFESP]
dc.contributor.authorMelo-Thomas, Liana [UNIFESP]
dc.contributor.authorSilva, Regina Cláudia Barbosa da [UNIFESP]
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.date.accessioned2016-01-24T14:34:43Z
dc.date.available2016-01-24T14:34:43Z
dc.date.issued2013-11-15
dc.description.abstractPatients with schizophrenia exhibit deficits in an operational measure of sensorimotor gating: prepulse inhibition (PPI) of startle. PPI is the normal reduction in the startle response caused by a low intensity non-startling stimulus (prepulse) which is presented shortly before the startle stimulus (pulse). MK-801 is an NMDA receptor-antagonist known to produce hyperactivity, deficits in prepulse inhibition and social withdrawal, behaviors which correlate well with some of the positive, cognitive and negative symptoms of schizophrenia. the inferior colliculus (IC) is a critical part of the auditory pathway mediating acoustic PPI. the activation of the IC by the acoustic prepulse reduces startle magnitude. Thus, the purpose of the present study was to elucidate the role of glutamatergic transmission in the IC on the expression of acoustic PPI. for that we investigated whether NMDA receptor stimulation or blockade would affect this response. Unilateral microinjections of NMDA (30 nmol/0.5 mu L) into the IC did not alter PPI while microinjections of MK-801 (30 nmol/0.5 mu L) into this structure disrupted PPI. We also examined the ability of the atypical antipsychotic olanzapine (5.0 mg/kg; i.p.) to reverse the disruption of pre-pulse inhibition produced by unilateral microinjections of MK-801 into the IC of rats. Pretreatment with olanzapine blocked MK-801-induced disruption of PPI. Altogether, these results suggest that glutamate-mediated mechanisms of the IC are involved in the expression of PPI in rodents and that this response is sensitive to atypical antipsychotic olanzapine. (C) 2013 Elsevier B.V. All rights reserved.en
dc.description.affiliationUniversidade Federal de São Paulo Unifesp, Dept Biociencias, Lab Psicol Expt, BR-11060001 Santos, SP, Brazil
dc.description.affiliationUniversidade Federal de São Paulo Unifesp, Dept Fisiol, Lab Neurofisiol, BR-04023066 São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo Unifesp, Dept Biociencias, Lab Psicol Expt, BR-11060001 Santos, SP, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo Unifesp, Dept Fisiol, Lab Neurofisiol, BR-04023066 São Paulo, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)pt
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)pt
dc.description.sponsorshipIDFAPESP: 2012/01062-7pt
dc.description.sponsorshipIDFAPESP: 2011/01409-4pt
dc.description.sponsorshipIDFAPESP: 2012/05021-3pt
dc.description.sponsorshipIDFAPESP: 2012/06275-9pt
dc.description.sponsorshipIDFAPESP: 2010/14446-2pt
dc.format.extent77-82
dc.identifierhttps://dx.doi.org/10.1016/j.bbr.2013.09.018
dc.identifier.citationBehavioural Brain Research. Amsterdam: Elsevier B.V., v. 257, p. 77-82, 2013.
dc.identifier.doi10.1016/j.bbr.2013.09.018
dc.identifier.issn0166-4328
dc.identifier.urihttps://repositorio.unifesp.br/handle/11600/36982
dc.identifier.wosWOS:000328519200011
dc.language.isoeng
dc.publisherElsevier B.V.
dc.relation.ispartofBehavioural Brain Research
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.rights.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dc.subjectNMDAen
dc.subjectMK-801en
dc.subjectOlanzapineen
dc.subjectInferior colliculusen
dc.subjectPrepulse inhibitionen
dc.subjectSchizophreniaen
dc.titleAtypical antipsychotic olanzapine reversed deficit on prepulse inhibition of the acoustic startle reflex produced by microinjection of dizocilpine (MK-801) into the inferior colliculus in ratsen
dc.typeinfo:eu-repo/semantics/article
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