Adipokine Profile and Urinary Albumin Excretion in Isolated Growth Hormone Deficiency

dc.contributor.authorOliveira, Carla R. P.
dc.contributor.authorSalvatori, Roberto
dc.contributor.authorMeneguz-Moreno, Rafael A.
dc.contributor.authorAguiar-Oliveira, Manuel H.
dc.contributor.authorPereira, Rossana M. C.
dc.contributor.authorValenca, Eugenia H. A.
dc.contributor.authorAraujo, Vanessa P.
dc.contributor.authorFarias, Natalia T.
dc.contributor.authorSilveira, Debora C. R.
dc.contributor.authorVieira, Jose Gilberto Henriques [UNIFESP]
dc.contributor.authorBarreto-Filho, Jose A. S.
dc.contributor.institutionJohns Hopkins Univ
dc.contributor.institutionUniv Fed Sergipe
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.description.abstractBackground: GH deficiency (GHD) is often associated with cardiovascular risk factors, including abdominal fat accumulation, hypercholesterolemia, and increased C-reactive protein. Despite the presence of these risk factors, adults with congenital lifetime isolated GHD (IGHD) due to an inactivating mutation in the GHRH receptor gene do not have premature atherosclerosis.Objective: the aim was to study the serum levels of adiponectin and leptin (antiatherogenic and atherogenic adipokine, respectively), and the urinary albumin excretion (UAE) in these IGHD individuals.Design and Patients: We conducted a cross-sectional study of 20 IGHD individuals (seven males; age, 50.8 +/- 14.6 yr) and 22 control subjects (eight males; age, 49.9 +/- 11.5 yr).Main Outcome Measures: Anthropometric factors, body composition, blood pressure, serum adiponectin, leptin, and UAE were measured.Results: Adiponectin was higher [12.8 (7.1) vs. 9.7 (5) ng/ml; P = 0.041] in IGHD subjects, whereas no difference was observed in leptin [7.3 (6.3) vs. 9.3 (18.7 ng/ml] and UAE [8.6 (13.8) vs. 8.5 (11.1) mu g/min].Conclusions: Subjects with lifetime untreated IGHD have an adipokine profile with high adiponectin and normal leptin levels that may delay vascular damage and lesions of the renal endothelium. (J Clin Endocrinol Metab 95: 693-698, 2010)en
dc.description.affiliationJohns Hopkins Univ, Sch Med, Div Endocrinol, Baltimore, MD 21287 USA
dc.description.affiliationUniv Fed Sergipe, Div Endocrinol, BR-49060100 Aracaju, SE, Brazil
dc.description.affiliationEscola Paulista Med, Div Endocrinol, BR-04034970 São Paulo, Brazil
dc.description.affiliationUnifespEscola Paulista Med, Div Endocrinol, BR-04034970 São Paulo, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipNational Institutes of Health
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.description.sponsorshipIDNational Institutes of Health: 1R01 DK065718
dc.description.sponsorshipIDCAPES: BEX 4309/08-1
dc.identifier.citationJournal of Clinical Endocrinology & Metabolism. Chevy Chase: Endocrine Soc, v. 95, n. 2, p. 693-698, 2010.
dc.publisherEndocrine Soc
dc.relation.ispartofJournal of Clinical Endocrinology & Metabolism
dc.rightsAcesso aberto
dc.titleAdipokine Profile and Urinary Albumin Excretion in Isolated Growth Hormone Deficiencyen