Renal abnormalities in a cohort of HIV-infected children and adolescents

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dc.citation.issue5
dc.citation.volume31
dc.contributor.authorLeão, Flavia Vanesca Felix [UNIFESP]
dc.contributor.authorSucci, Regina Célia de Menezes [UNIFESP]
dc.contributor.authorMachado, Daisy Maria [UNIFESP]
dc.contributor.authorGouvea, Aida de Fatima Thome Barbosa [UNIFESP]
dc.contributor.authorCarmo, Fabiana Bononi do [UNIFESP]
dc.contributor.authorBeltrao, Suenia Vasconcelos [UNIFESP]
dc.contributor.authorCançado, Maria Aparecida de Paula [UNIFESP]
dc.contributor.authorCarvalhaes, Joo Tomas de Abreu [UNIFESP]
dc.coverageNew York
dc.date.accessioned2020-07-22T13:23:05Z
dc.date.available2020-07-22T13:23:05Z
dc.date.issued2016
dc.description.abstractBackground This study aimed to identify the prevalence of renal abnormalities and the evolution of glomerular filtration rate (GFR) among human immunodeficiency virus (HIV)-infected children and adolescents followed up in an infectious disease outpatient pediatric clinic. Methods We performed a cohort study of 115 children and adolescents. Outcomes of two evaluations for urinalysis, microalbuminuria/urinary creatinine ratio, urinary retinol-binding protein (uRBP) concentration, and estimated GFR (eGFR) were obtained for each patient, with an average interval of 6 months between evaluations. These changes were correlated with gender, age, race, body mass index (BMI), height-for-age (H/A) percentile, clinical and immunological classification of HIV infection, use of antiretroviral therapy (ART), HIV viral load (VL), and CD4+ T-lymphocyte count. Results Mean patient age at the time of inclusion in the study was 12.6 +/- 3.2 yearsen
dc.description.abstract50.4 % were male, 81.7 % had acquired immune defeciency syndrome (AIDS), 80.9 % had CD4+ < 500 cells/mm(3), and 87.8 % were on ART. Urinary changes included hematuria (11.3 %), proteinuria (7 %), and microalbuminuria (11.6 %)en
dc.description.abstractuRBP was present in 3.8 %en
dc.description.abstractand mean eGFR was 163 +/- 32 ml/min/1.73 m(2). Conclusions The subclinical renal abnormalities found in this study may indicate early manifestations of a broad spectrum of renal dysfunction associated with HIV and involves the decision to initiate or modify ART.en
dc.description.affiliationUniv Fed Sao Paulo, Escola Paulista Med, Pediat Nephrol Div, Rua Borges Lagoa,442 V1 Clementino, BR-04038030 Sao Paulo, SP, Brazil
dc.description.affiliationUniv Fed Sao Paulo, Escola Paulista Med, Pediat Infect Dis Div, BR-04038030 Sao Paulo, SP, Brazil
dc.description.affiliationUnifespUniv Fed Sao Paulo, Escola Paulista Med, Pediat Nephrol Div, Rua Borges Lagoa,442 V1 Clementino, BR-04038030 Sao Paulo, SP, Brazil
dc.description.affiliationUnifespUniv Fed Sao Paulo, Escola Paulista Med, Pediat Infect Dis Div, BR-04038030 Sao Paulo, SP, Brazil
dc.description.sourceWeb of Science
dc.format.extent773-778
dc.identifierhttp://dx.doi.org/10.1007/s00467-015-3260-x
dc.identifier.citationPediatric Nephrology. New York, v. 31, n. 5, p. 773-778, 2016.
dc.identifier.doi10.1007/s00467-015-3260-x
dc.identifier.issn0931-041X
dc.identifier.urihttps://repositorio.unifesp.br/handle/11600/56026
dc.identifier.wosWOS:000373305100010
dc.language.isoeng
dc.publisherSpringer
dc.relation.ispartofPediatric Nephrology
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.subjectChildrenen
dc.subjectHuman immunodeficiency virusen
dc.subjectRenal dysfunctionen
dc.subjectAdolescentsen
dc.subjectProteinuriaen
dc.subjectHyperfiltrationen
dc.titleRenal abnormalities in a cohort of HIV-infected children and adolescentsen
dc.typeinfo:eu-repo/semantics/article
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