Cytokine gene variants and venous thrombotic risk in the BRATROS (BRAZILIAN THROMBOSIS STUDY)

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dc.contributor.authorPieroni, Fabiano
dc.contributor.authorLourenco, Dayse M.
dc.contributor.authorMorelli, Vania M.
dc.contributor.authorMaffei, Francisco H.
dc.contributor.authorZago, Marco A.
dc.contributor.authorFranco, Rendrik F.
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.contributor.institutionState Univ Sao Paolo
dc.contributor.institutionFleury Res Inst
dc.date.accessioned2016-01-24T12:41:45Z
dc.date.available2016-01-24T12:41:45Z
dc.date.issued2007-01-01
dc.description.abstractIntroduction: Venous thrombosis (VT) and inflammation are two closely related entities. in the present investigation we assessed whether there is a relation between genetic modifiers of the inflammatory response and the risk of VT.Materials and methods: 420 consecutive and unrelated patients with an objective diagnosis of deep VT and 420 matched controls were investigated. the frequencies of the following gene polymorphisms were determined in all subjects: TNF-alpha-308 G/A, LT-alpha+252 A/G, IL-6-174 G/C, IL1-ra 86 bp VNTR, IL-10-1082 A/G and CD-31 125 C/G.Results: Overall odds ratio (OR) for VT related to TNF-alpha-308 G/A, LT-alpha+252 A/G, IL-6-174 G/C, Al allele (4 bp repeat) of the IL1 -ra 86 bp VNTR, IL-10-1082 A/G and CD-31 125 C/G were respectively: 1.0 (CI95: 0.8-1.5), 1.3 (095: 1.0-1.7), 1.1 (CI95: 0.9-1.5), 1.6 (CI95: 1-2.5), 1.2 (CI95: 0.8-1.7) and 0.8 (CI95: 0.6-1.1). A possible interaction between polymorphisms was observed only for the co-inheritance of the mutant alleles of the LT-alpha+252 A/G and IL-10-1082 G/A polymorphisms (OR=2; CI95: 1.1-3.8). the risk of VT conferred by factor V Leiden and FII G20210A was not substantially altered by co-inheritance with any of the cytokine gene polymorphisms.Conclusions: Cytokine gene polymorphisms here investigated did not significantly influence venous thrombotic risk. (C) 2006 Elsevier B.V. All rights reserved.en
dc.description.affiliationUniv São Paulo, Sch Med Ribeirao Preto, BR-05508 São Paulo, Brazil
dc.description.affiliationUniversidade Federal de São Paulo, São Paulo, Brazil
dc.description.affiliationState Univ Sao Paolo, São Paulo, Brazil
dc.description.affiliationFleury Res Inst, São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, São Paulo, Brazil
dc.description.sourceWeb of Science
dc.format.extent221-229
dc.identifierhttp://dx.doi.org/10.1016/j.thromres.2006.09.015
dc.identifier.citationThrombosis Research. Oxford: Pergamon-Elsevier B.V., v. 120, n. 2, p. 221-229, 2007.
dc.identifier.doi10.1016/j.thromres.2006.09.015
dc.identifier.issn0049-3848
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/29394
dc.identifier.wosWOS:000247198700010
dc.language.isoeng
dc.publisherElsevier B.V.
dc.relation.ispartofThrombosis Research
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.rights.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dc.subjectthrombosisen
dc.subjectvenous thromboembolismen
dc.subjectpolymorphismsen
dc.subjectcytokinesen
dc.subjectcoagulationen
dc.subjectinflammationen
dc.titleCytokine gene variants and venous thrombotic risk in the BRATROS (BRAZILIAN THROMBOSIS STUDY)en
dc.typeinfo:eu-repo/semantics/article
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