Botulinum toxin for oropharyngeal dysphagia: case report of flexible endoscope-guided injection

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dc.contributor.authorBrant, C. Q.
dc.contributor.authorSiqueira, E. S.
dc.contributor.authorFerrari, A. P.
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.date.accessioned2016-01-24T12:30:44Z
dc.date.available2016-01-24T12:30:44Z
dc.date.issued1999-01-01
dc.description.abstractBotulinnm toxin (BT) has been used in neurology, ophthalmology, otorhinolaryngology and gastroenterology. Twenty-four patients with oropharyngeal dysphagia treated with BT injection into the cricopharyngeal muscle were reported, with good results in up to 79% of the patients, Different techniques were used to inject BT: percutaneous (guided by electromyography, computed tomography or videofluoroscopy) or direct injection during esophagoscopy (with a rigid esophagoscope), We report the first case of oropharyngeal dysphagia treated by BT injection into the cricopharyngeal muscle using a flexible scope, with clinical, radiological and manometric improvement.A reduction in the disability score 4 to 2 and sustained capacity to maintain adequate oral caloric intake were observed. the patient was also able to have the tracheotomy orifice closed and the gastrostomy tube removed after 3 months, Manometry showed a 38% reduction in the upper esophageal sphincter pressure with the presence of pharyngeal waves that were previously absent. After 1 year of follow-up, the patient was in good condition with mild dysphagia for solid foods. This is another case of complex dysphagia and relative hyperfunction of the cricopharyngeal muscle successfully treated with BT injection.en
dc.description.affiliationUniversidade Federal de São Paulo, Div Gastroenterol, São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Div Gastroenterol, São Paulo, Brazil
dc.description.sourceWeb of Science
dc.format.extent68-73
dc.identifierhttp://dx.doi.org/10.1046/j.1442-2050.1999.00015.x
dc.identifier.citationDiseases of the Esophagus. Carlton: Blackwell Science Asia, v. 12, n. 1, p. 68-73, 1999.
dc.identifier.doi10.1046/j.1442-2050.1999.00015.x
dc.identifier.issn1120-8694
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/26013
dc.identifier.wosWOS:000083699500015
dc.language.isoeng
dc.publisherBlackwell Science Asia
dc.relation.ispartofDiseases of the Esophagus
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.titleBotulinum toxin for oropharyngeal dysphagia: case report of flexible endoscope-guided injectionen
dc.typeinfo:eu-repo/semantics/article
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