Post-sensitization treatment with rimonabant blocks the expression of cocaine-induced behavioral sensitization and c-Fos protein in mice

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dc.citation.volume156
dc.contributor.author Marinho, Eduardo Ary Villela
dc.contributor.authorOliveira-Lima, Alexandre Justo de
dc.contributor.authorYokoyama, Thais Suemi [UNIFESP]
dc.contributor.authorSantos-Baldaia, Renan [UNIFESP]
dc.contributor.authorRibeiro, Luciana Takahashi Carvalho [UNIFESP]
dc.contributor.authorBaldaia, Marilia Araujo [UNIFESP]
dc.contributor.authorWuo-Silva, Raphael [UNIFESP]
dc.contributor.authorHollais, André Willian [UNIFESP]
dc.contributor.authorTalhati, Fernanda [UNIFESP]
dc.contributor.authorLongo, Beatriz Monteiro [UNIFESP]
dc.contributor.authorBerro, Laís Fernanda [UNIFESP]
dc.contributor.authorFrussa-Filho, Roberto [UNIFESP]
dc.coverageOxford
dc.date.accessioned2020-07-13T11:53:25Z
dc.date.available2020-07-13T11:53:25Z
dc.date.issued2017
dc.description.abstractCB1 receptor antagonists have been shown to prevent acute and long-term behavioral effects of cocaine. Here we evaluate the effectiveness of the CB1 receptor antagonist rimonabant to modify sensitized responses to cocaine. Mice were treated with saline or cocaine injections in a 15-day intermittent sensitization treatment and subsequently treated with either vehicle, 1 or 10 mg/kg rimonabant in the drug-associated environment for 8 consecutive days. Animals were then challenged with saline and cocaine in the open-field apparatus on subsequent days to evaluate the expression of conditioned and sensitized effects to cocaine. c-Fos protein expression was evaluated in the nucleus accumbens (NAcc), ventral tegmental area (VTA), basolateral amygdala (BLA), medial prefrontal cortex (mPFC) and caudate-putamen (CPu) after the last (cocaine) challenge. Previous treatment with 10 mg/kg rimonabant blocked the expression of conditioned hyperlocomotion and behavioral sensitization to cocaine, but not acute cocaine-induced hyperlocomotion. These behavioral effects were accompanied by significant changes in c-Fos expression in the brain reward system. Chronic cocaine sensitization blunted a subsequent acute cocaine-induced increase in c-Fos protein in the NAcc, effect that was reversed by previous treatment with rimonabant. Treatment with 10 mg/kg rimonabant also attenuated the significant increase in c-Fos expression in the CPu, mPFC and BLA induced by previous chronic sensitization with cocaine. Our findings add to the evidence that drugs targeting CB1 receptors are good candidates for the treatment of cocaine abuse and provide further insights into the mechanisms underlying endocannabinoid signaling within the brain reward system in the context of cocaine abuse.en
dc.description.affiliationUniv Estadual Santa Cruz, Dept Hlth Sci, Rod Ilheus Itabuna,Km 16, BR-456620 Ilheus, BA, Brazil
dc.description.affiliationUniv Fed Sao Paulo, Dept Physiol, R Botucatu 862, Sao Paulo, SP, Brazil
dc.description.affiliationUniv Fed Sao Paulo, Dept Pharmacol, R Botucatu 862, Sao Paulo, SP, Brazil
dc.description.affiliationUniv Fed Sao Paulo, Dept Psychobiol, R Botucatu 862, Sao Paulo, SP, Brazil
dc.description.affiliationUnifespUniv Fed Sao Paulo, Dept Physiol, R Botucatu 862, Sao Paulo, SP, Brazil
dc.description.affiliationUnifespUniv Fed Sao Paulo, Dept Pharmacol, R Botucatu 862, Sao Paulo, SP, Brazil
dc.description.affiliationUnifespUniv Fed Sao Paulo, Dept Psychobiol, R Botucatu 862, Sao Paulo, SP, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipFundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP)
dc.description.sponsorshipConselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPq)
dc.description.sponsorshipCoordenacao de Aperfeicoamento de Pessoal de Nivel Superior (CAPES)
dc.description.sponsorshipAssociacao Fundo de Incentivo a Pesquisa (AFIP)
dc.format.extent16-23
dc.identifierhttps://dx.doi.org/10.1016/j.pbb.2017.03.006
dc.identifier.citationPharmacology Biochemistry And Behavior. Oxford, v. 156, p. 16-23, 2017.
dc.identifier.doi10.1016/j.pbb.2017.03.006
dc.identifier.fileWOS000401314500003.pdf
dc.identifier.issn0091-3057
dc.identifier.urihttps://repositorio.unifesp.br/handle/11600/54608
dc.identifier.wosWOS:000401380500003
dc.language.isoeng
dc.publisherPergamon-Elsevier Science Ltd
dc.relation.ispartofPharmacology Biochemistry And Behavior
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectBehavioral sensitizationen
dc.subjectCannabinoiden
dc.subjectC-Fos expressionen
dc.subjectCocaineen
dc.subjectConditioningen
dc.subjectRimonabanten
dc.titlePost-sensitization treatment with rimonabant blocks the expression of cocaine-induced behavioral sensitization and c-Fos protein in miceen
dc.typeinfo:eu-repo/semantics/article
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