Use of stem cells cultured ex vivo for ocular surface reconstruction

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dc.contributor.authorRicardo, Jose Reinaldo da Silva [UNIFESP]
dc.contributor.authorGomes, José Álvaro Pereira [UNIFESP]
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.date.accessioned2016-01-24T14:05:37Z
dc.date.available2016-01-24T14:05:37Z
dc.date.issued2010-11-01
dc.description.abstractLesions on the ocular surface can destroy the stem cells from the limbus and cause limbal stem cell deficiency. the limbal stem cell deficiency is marked by conjunctivalization, which can be defined as the invasion of conjunctival epithelium over the cornea. This process is accompanied by varying degrees of corneal changes such as neovascularization, inflammation, recurrent erosions, persistent epithelial defects, destruction of basement membrane of epithelium and stromal healing. Often, these changes are associated with poor visual acuity, photophobia and ocular discomfort. the best treatment for this disease is not known and varies in unilateral or bilateral cases. Among the treatments available, transplantation of limbal autograft or allograft is one of the most used. To improve the outcome of allotransplantation, some researchers use the transplantation of corneal epithelium cultured in the laboratory by ex vivo expansion of limbal stem cells, but due to limited availability of autologous tissue from the limbus and the risk of complications associated with immuno-suppression in allogeneic tissue transplantation, researches of others options of stem cell cultured ex vivo have been described in experimental and clinical stage. This review describes the new types of stem cells cultured ex vivo, their current results and future potential.en
dc.description.affiliationUniversidade Federal de São Paulo, CASO, Setor Doencas Oculares Externas & Cornea, Dept Oftalmol, São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, CASO, Setor Doencas Oculares Externas & Cornea, Dept Oftalmol, São Paulo, Brazil
dc.description.sourceWeb of Science
dc.format.extent541-547
dc.identifierhttp://dx.doi.org/10.1590/S0004-27492010000600017
dc.identifier.citationArquivos Brasileiros de Oftalmologia. São Paulo: Consel Brasil Oftalmologia, v. 73, n. 6, p. 541-547, 2010.
dc.identifier.doi10.1590/S0004-27492010000600017
dc.identifier.fileS0004-27492010000600017.pdf
dc.identifier.issn0004-2749
dc.identifier.scieloS0004-27492010000600017
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/33017
dc.identifier.wosWOS:000286609700016
dc.language.isopor
dc.publisherConsel Brasil Oftalmologia
dc.relation.ispartofArquivos Brasileiros de Oftalmologia
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectAdult stem cells/transplantationen
dc.subjectAmnionen
dc.subjectCell culture techniques/methodsen
dc.subjectEpithelial cells/transplantationen
dc.subjectKeratoconjunctivitis/surgeryen
dc.subjectLimbus cornea/cytologyen
dc.subjectTreatment outcomeen
dc.titleUse of stem cells cultured ex vivo for ocular surface reconstructionen
dc.typeinfo:eu-repo/semantics/article
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