Paradoxical sleep deprivation and sleep recovery: Effects on the hypothalamic-pituitary-adrenal axis activity, energy balance and body composition of rats

Página do item simplificado
dc.contributor.authorHipolide, D. C.
dc.contributor.authorSuchecki, D.
dc.contributor.authorPinto, APD
dc.contributor.authorFaria, E. C.
dc.contributor.authorTufik, S.
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.contributor.institutionUniv Calif Riverside
dc.date.accessioned2016-01-24T12:41:05Z
dc.date.available2016-01-24T12:41:05Z
dc.date.issued2006-04-01
dc.description.abstractNumerous studies indicate that sleep deprivation alters energy expenditure. However, this conclusion is drawn from indirect measurements. in the present study, we investigated alterations of energy expenditure, body composition, blood glucose levels, plasma insulin, adrenocorticotropic hormone (ACTH) and corticosterone levels immediately after 4 days of sleep deprivation or after 4 days of sleep recovery. Rats were sleep deprived or maintained in a control environment (groups sleep-deprived/deprivation and control/deprivation). One half of these animals were sacrificed at the end of the deprivation period and the other half was transported to metabolic cages, where they were allowed to sleep freely (groups sleep-deprived/recovery and control/recovery). At the end of the sleep recovery period, these rats were sacrificed. After sleep deprivation, sleep-deprived rats exhibited loss of body weight, augmented energy expenditure and reduced metabolic efficiency compared to control rats. These alterations were normalised during the sleep recovery period. the body composition of sleep-deprived rats was altered insofar as there was a loss of fat content and gain of protein content in the carcass compared to control rats. However, these alterations were not reversed by sleep recovery. Finally, plasma levels of insulin were reduced during the sleep deprivation period in both control and sleep deprived groups compared to the recovery period. After the deprivation period, plasma ACTH and corticosterone levels were increased in sleep-deprived rats compared to control rats, and although ACTH levels were similar between the groups after the sleep recovery period, corticosterone levels remained elevated in sleep-deprived rats after this period. By means of direct measurements of metabolism, our results showed that sleep deprivation produces increased energy expenditure and loss of fat content. Most of the alterations were reversed by sleep recovery, except for corticosterone levels and body composition.en
dc.description.affiliationUniversidade Federal de São Paulo, Escola Paulista Med, Dept Psychobiol, BR-04024002 São Paulo, Brazil
dc.description.affiliationUniversidade Federal de São Paulo, Escola Paulista Med, Dept Physiol, BR-04024002 São Paulo, Brazil
dc.description.affiliationUniv Calif Riverside, Dept Cell Biol & Neurosci, Riverside, CA 92521 USA
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Escola Paulista Med, Dept Psychobiol, BR-04024002 São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Escola Paulista Med, Dept Physiol, BR-04024002 São Paulo, Brazil
dc.description.sourceWeb of Science
dc.format.extent231-238
dc.identifierhttp://dx.doi.org/10.1111/j.1365-2826.2006.01412.x
dc.identifier.citationJournal of Neuroendocrinology. Oxford: Blackwell Publishing, v. 18, n. 4, p. 231-238, 2006.
dc.identifier.doi10.1111/j.1365-2826.2006.01412.x
dc.identifier.issn0953-8194
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/28834
dc.identifier.wosWOS:000235538800001
dc.language.isoeng
dc.publisherBlackwell Publishing
dc.relation.ispartofJournal of Neuroendocrinology
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.subjectparadoxical sleep deprivationen
dc.subjectsleep recoveryen
dc.subjectenergy balanceen
dc.subjectbody compositionen
dc.subjecthypothalamic-pituitary-adrenal axisen
dc.titleParadoxical sleep deprivation and sleep recovery: Effects on the hypothalamic-pituitary-adrenal axis activity, energy balance and body composition of ratsen
dc.typeinfo:eu-repo/semantics/article
Arquivos
Coleções
Em verificação - Geral