Mast cell concentration and skin wound contraction in rats treated with Ximenia americana L

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dc.citation.issue2
dc.citation.volume32
dc.contributor.authorSouza Neto Junior, Jose de Castro
dc.contributor.authorde Moura Estevao, Ligia Reis
dc.contributor.authorBaratella-Evencio, Liriane
dc.contributor.authorFeitosa Vieira, Marcela Gabriela
dc.contributor.authorSimoes, Ricardo Santos
dc.contributor.authorFlorencio-Silva, Rinaldo [UNIFESP]
dc.contributor.authorEvencio-Luz, Luis
dc.contributor.authorEvencio-Neto, Joaquim
dc.coverageSao Paulo
dc.date.accessioned2020-07-17T14:03:04Z
dc.date.available2020-07-17T14:03:04Z
dc.date.issued2017
dc.description.abstractPURPOSE: To evaluate wound contraction and the concentration of mast cells in skin wounds treated with wild plum (Ximenia americana) essential oil-based ointment in rats. METHODS:Sixty rats were submitted to two cutaneous wounds in the thoracic region, on the right and left antimeres. Thereon, they were divided into three groups: GX (wounds treated once a day with hydro alcoholic branch extract of Ximenia americana), GP (wounds that received vehicle), and GC (wounds without product application). Wounds were measured immediately after the injury as well as 4, 7, 14 and 21 days post-topical application of the extract. At these days, five rats from each group were euthanatized. Thereafter, samples were fixed in 10% formaldehyde and processed for paraffin embedding. Sections were stained with H.E, Masson's Trichrome and toluidine blue for morphological, morphometrical and histopathological analysis, under light microscopy. The degree of epithelial contraction was measured and mast cell concentrations were also evaluated with an image analyzer (Image Pro-plus (R) software). RESULTS: The extract treated group showed lower mast cell concentrations in the 4th day of lesion, as compared to GP (GX<GP=GC, p=0.029), as well as with increased contraction at 7th and 14th days, respectively (7th and 14th days, GX > GP = GCen
dc.description.abstractp<0.05). CONCLUSION: Ointment containing 10% X. americana induces a decrease in mast cell concentration, at the beginning of the healing process, and promotes early skin wound contraction in rats.en
dc.description.affiliationUniv Fed Rio Grande do Norte UFRN, Dept Morphol & Anim Physiol, Postgrad Program Anim Biosci, Recife, PE, Brazil
dc.description.affiliationUniv Fed Rural Pernambuco UFRPE, Dept Morphol & Anim Physiol, Postgrad Program Anim Biosci, Recife, PE, Brazil
dc.description.affiliationUniv Fed Pernambuco UFPE, Dept Histol & Embryol, Histol Div, Recife, PE, Brazil
dc.description.affiliationUniv Fed Rural Pernambuco, Dept Morphol & Anim Physiol, Postgrad Program Anim Biosci, Recife, PE, Brazil
dc.description.affiliationUniv Sao Paulo FMUSP, Fac Med, Clin Hosp, Sao Paulo, Brazil
dc.description.affiliationUniv Fed Sao Paulo UNIFESP, Dept Morphol & Genet, Postgrad Program Morphol, Sao Paulo, Brazil
dc.description.affiliationUniv Fed Piaui, Dept Biol, Div Microbiol, Picos, PI, Brazil
dc.description.affiliationUniv Fed Rural Pernambuco, Dept Morphol & Physiol, Anat Div, Recife, PE, Brazil
dc.description.affiliationUnifespUniv Fed Sao Paulo UNIFESP, Dept Morphol & Genet, Postgrad Program Morphol, Sao Paulo, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipFACEPE
dc.description.sponsorshipFAPEMIG
dc.description.sponsorshipCNPq
dc.format.extent148-156
dc.identifierhttp://dx.doi.org/10.1590/s0102-865020170207
dc.identifier.citationActa Cirurgica Brasileira. Sao Paulo, v. 32, n. 2, p. 148-156, 2017.
dc.identifier.doi10.1590/s0102-865020170207
dc.identifier.fileWOS000396341600007.pdf
dc.identifier.issn0102-8650
dc.identifier.urihttps://repositorio.unifesp.br/handle/11600/55147
dc.identifier.wosWOS:000396341600007
dc.language.isoeng
dc.publisherActa Cirurgica Brasileira
dc.relation.ispartofActa Cirurgica Brasileira
dc.rightsAcesso aberto
dc.subjectWound Healingen
dc.subjectPhytotherapyen
dc.subjectMast Cellsen
dc.subjectSkinen
dc.subjectRatsen
dc.titleMast cell concentration and skin wound contraction in rats treated with Ximenia americana Len
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