A Rheumatoid arthritis study using Raman spectroscopy

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dc.contributor.authorCarvalho, C. S.
dc.contributor.authorMartin, A. A.
dc.contributor.authorSanto, A. M. E. [UNIFESP]
dc.contributor.authorAndrade, L. E. C. [UNIFESP]
dc.contributor.authorPinheiro, M. M. [UNIFESP]
dc.contributor.authorCardoso, M. A. G.
dc.contributor.authorRaniero, L.
dc.contributor.institutionUniv Vale Paraiba
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.date.accessioned2016-01-24T14:17:30Z
dc.date.available2016-01-24T14:17:30Z
dc.date.issued2011-12-01
dc.description.abstractRheumatoid arthritis (RA) is characterized by chronic inflammation of the joints and can lead to a progressive destruction of articular cartilage and bone. in this study, the specificity and sensitivity of the RA diagnostic methods based on the receiver-operating characteristic curves for monitoring C-reactive protein (CRP) and rheumatoid factor (RF) were compared with the Raman spectroscopic diagnostic method developed in this work. Sera from 24 patients with rheumatoid arthritis and from 16 healthy individuals were analyzed to assess the biochemical composition and presence of inflammatory activity by the aforementioned methods. By comparing with the clinical results for specificity and sensitivity from the RF and CRP tests, we show that the overall results from the newly developed Raman method were significantly better, with a specificity of 96%, a sensitivity of 88%, and correctly identifying 92% of the RA and healthy individuals, while the RF test gave a specificity of 100% and a sensitivity of 54%, and the CRP test gave a specificity of 87% and a sensitivity of 58%, respectively.en
dc.description.affiliationUniv Vale Paraiba, UnivVaP, Lab Biomed Vibrat Spect, BR-12244400 São Paulo, Brazil
dc.description.affiliationUniversidade Federal de São Paulo, UniFeSP, Dept Ciencias Exatas & Terra, BR-09972270 São Paulo, Brazil
dc.description.affiliationUniversidade Federal de São Paulo, UniFeSP, Dept Med, Div Reumatol, BR-04023062 São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, UniFeSP, Dept Ciencias Exatas & Terra, BR-09972270 São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, UniFeSP, Dept Med, Div Reumatol, BR-04023062 São Paulo, Brazil
dc.description.sourceWeb of Science
dc.format.extent1211-1220
dc.identifierhttp://dx.doi.org/10.1007/s00214-011-0905-0
dc.identifier.citationTheoretical Chemistry Accounts. New York: Springer, v. 130, n. 4-6, p. 1211-1220, 2011.
dc.identifier.doi10.1007/s00214-011-0905-0
dc.identifier.issn1432-881X
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/34274
dc.identifier.wosWOS:000297373800055
dc.language.isoeng
dc.publisherSpringer
dc.relation.ispartofTheoretical Chemistry Accounts
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.rights.licensehttp://www.springer.com/open+access/authors+rights?SGWID=0-176704-12-683201-0
dc.subjectConfocal Ramanen
dc.subjectRheumatoid arthritisen
dc.subjectSerumen
dc.titleA Rheumatoid arthritis study using Raman spectroscopyen
dc.typeinfo:eu-repo/semantics/article
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