Increased blood pressure and water intake in transgenic mice expressing rat tonin in the brain

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dc.contributor.authorCardoso, Cibele C.
dc.contributor.authorAlenina, Natalia
dc.contributor.authorFerreira, Anderson J.
dc.contributor.authorQadri, Fatimunnisa
dc.contributor.authorLima, Mercia P.
dc.contributor.authorGross, Volkmar
dc.contributor.authorTodiras, Mihail
dc.contributor.authorPesquero, Joao B. [UNIFESP]
dc.contributor.authorPesquero, Jorge L.
dc.contributor.authorBader, Michael
dc.contributor.institutionMax Delbruck Ctr Mol Med
dc.contributor.institutionUniversidade Federal de Minas Gerais (UFMG)
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.date.accessioned2016-01-24T13:59:34Z
dc.date.available2016-01-24T13:59:34Z
dc.date.issued2010-04-01
dc.description.abstractTonin is a serine proteinase of the kallikrein family that can produce angiotensin II directly from angiotensinogen. To clarify the importance of this enzyme for central nervous control of the cardiovascular system, we generated transgenic mice. TGM(rTon), that express rat tonin in astrocytes. These mice present high levels of tonin mRNA and activity specifically in the brain. As a consequence. TGM(rTon) develop increased blood pressure and water intake. Lisinopril, an ACE inhibitor, is less hypotensive for transgenic mice than for control animals. the AT(I) receptor antagonist candesartan equally lowers blood pressure in transgenic and in control mice. Plasma angiotensin II, but not angiotensin I, is increased in TGM(rTon) compared to the wild type, suggesting release of the peptide from the brain into the circulation. However. AT(I) receptors are desensitized in this transgenic model, as demonstrated by a blunted pressor response to intravenous application of angiotensin II. in conclusion, tonin in the brain may represent an alternative pathway for angiotensin II generation with effects on the cardiovascular system.en
dc.description.affiliationMax Delbruck Ctr Mol Med, D-13125 Berlin, Germany
dc.description.affiliationUniv Fed Minas Gerais, BR-30270901 Belo Horizonte, MG, Brazil
dc.description.affiliationUniversidade Federal de São Paulo, BR-04023062 São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, BR-04023062 São Paulo, Brazil
dc.description.sourceWeb of Science
dc.format.extent435-441
dc.identifierhttp://dx.doi.org/10.1515/BC.2010.040
dc.identifier.citationBiological Chemistry. Berlin: Walter de Gruyter & Co, v. 391, n. 4, p. 435-441, 2010.
dc.identifier.doi10.1515/BC.2010.040
dc.identifier.issn1431-6730
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/32463
dc.identifier.wosWOS:000276338100014
dc.language.isoeng
dc.publisherWalter de Gruyter & Co
dc.relation.ispartofBiological Chemistry
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.subjectangiotensin IIen
dc.subjectblood pressureen
dc.subjecttoninen
dc.subjecttransgenic miceen
dc.titleIncreased blood pressure and water intake in transgenic mice expressing rat tonin in the brainen
dc.typeinfo:eu-repo/semantics/article
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