Effect of dietary lipids on circulating adiponectin: a systematic review with meta-analysis of randomised controlled trials

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dc.contributor.authorvon Frankenberg, Anize D.
dc.contributor.authorSilva, Flavia M.
dc.contributor.authorAlmeida, Jussara C. de
dc.contributor.authorPiccoli, Vanessa
dc.contributor.authorNascimento, Filipe V. do
dc.contributor.authorSost, Monica M.
dc.contributor.authorLeitao, Cristiane B.
dc.contributor.authorRemonti, Luciana L. R.
dc.contributor.authorUmpierre, Daniel
dc.contributor.authorReis, Andre F. [UNIFESP]
dc.contributor.authorCanani, Luis H.
dc.contributor.authorAzevedo, Mirela J. de
dc.contributor.authorGerchman, Fernando
dc.contributor.institutionUniv Fed Rio Grande do Sul
dc.contributor.institutionHosp Clin Porto Alegre
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.date.accessioned2016-01-24T14:38:01Z
dc.date.available2016-01-24T14:38:01Z
dc.date.issued2014-10-28
dc.description.abstractDifferent dietary interventions have been identified as potential modifiers of adiponectin concentrations, and they may be influenced by lipid intake. We identified studies investigating the effect of dietary lipids (type/amount) on adiponectin concentrations in a systematic review with meta-analysis. A literature search was conducted until July 2013 using databases such as Medline, Embase and Scopus (MeSH terms: adiponectin', dietary lipid', randomized controlled trials (RCT)'). Inclusion criteria were RCT in adults analysing adiponectin concentrations with modification of dietary lipids. Among the 4930 studies retrieved, fifty-three fulfilled the inclusion criteria and were grouped as follows: (1) total dietary lipid intake; (2) dietary/supplementary n-3 PUFA; (3) conjugated linoleic acid (CLA) supplementation; (4) other dietary lipid interventions. Diets with a low fat content in comparison to diets with a high-fat content were not associated with positive changes in adiponectin concentrations (twelve studies; pooled estimate of the difference in means: -004 (95% CI -082, 074)g/ml). A modest increase in adiponectin concentrations with n-3 PUFA supplementation was observed (thirteen studies; 027 (95% CI 007, 047)g/ml). Publication bias was found by using Egger's test (P=001) and funnel plot asymmetry. in contrast, CLA supplementation reduced the circulating concentrations of adiponectin compared with unsaturated fat supplementation (seven studies; -074 (95% CI -138, -010)g/ml). However, important sources of heterogeneity were found as revealed by the meta-regression analyses of both n-3 PUFA and CLA supplementation. Results of new RCT would be necessary to confirm these findings.en
dc.description.affiliationUniv Fed Rio Grande do Sul, Fac Med, Postgrad Endocrinol Program, Porto Alegre, RS, Brazil
dc.description.affiliationHosp Clin Porto Alegre, BR-90035003 Porto Alegre, RS, Brazil
dc.description.affiliationUniv Fed Rio Grande do Sul, Dept Internal Med, Porto Alegre, RS, Brazil
dc.description.affiliationHosp Clin Porto Alegre, Div Endocrinol, Metab Unit, Porto Alegre, RS, Brazil
dc.description.affiliationHosp Clin Porto Alegre, Exercise Pathophysiol Res Lab, Porto Alegre, RS, Brazil
dc.description.affiliationUniversidade Federal de São Paulo, Endocrinol Unit, São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Endocrinol Unit, São Paulo, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipFoundation for Research Support of the State of Rio Grande do Sul (FAPERGS)
dc.description.sponsorshipHospital de Clinicas de Porto Alegre Research Fund
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.description.sponsorshipInternational Scholarship Program of the Endocrine Society
dc.description.sponsorshipIDHospital de Clinicas de Porto Alegre Research Fund: FIPE 11-226
dc.format.extent1235-1250
dc.identifierhttp://dx.doi.org/10.1017/S0007114514002013
dc.identifier.citationBritish Journal of Nutrition. Cambridge: Cambridge Univ Press, v. 112, n. 8, p. 1235-1250, 2014.
dc.identifier.doi10.1017/S0007114514002013
dc.identifier.issn0007-1145
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/38343
dc.identifier.wosWOS:000343886000001
dc.language.isoeng
dc.publisherCambridge Univ Press
dc.relation.ispartofBritish Journal of Nutrition
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.rights.licensehttp://journals.cambridge.org/action/displaySpecialPage?pageId=4676
dc.subjectAdiponectinen
dc.subjectDietary lipidsen
dc.subjectn-3 PUFAen
dc.subjectConjugated linoleic aciden
dc.titleEffect of dietary lipids on circulating adiponectin: a systematic review with meta-analysis of randomised controlled trialsen
dc.typeinfo:eu-repo/semantics/article
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