Participation of the cholinergic system in the ethanol-induced suppression of paradoxical sleep in rats

Página do item simplificado
dc.contributor.authorPapale, Ligia Assumpção [UNIFESP]
dc.contributor.authorAndersen, Monica Levy [UNIFESP]
dc.contributor.authorPerry, Juliana Cini [UNIFESP]
dc.contributor.authorTufik, Sergio [UNIFESP]
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.date.accessioned2015-06-14T13:38:43Z
dc.date.available2015-06-14T13:38:43Z
dc.date.issued2008-09-01
dc.description.abstractSleep disturbance is among the many consequences of ethanol abuse in both humans and rodents. Ethanol consumption can reduce REM or paradoxical sleep (PS) in humans and rats, respectively. The first aim of this study was to develop an animal model of ethanol-induced PS suppression. This model administered intragastrically (by gavage) to male Wistar rats (3 months old, 200-250 g) 0.5 to 3.5 g/kg ethanol. The 3.5 g/kg dose of ethanol suppressed the PS stage compared with the vehicle group (distilled water) during the first 2-h interval (0-2 h; 1.3 vs 10.2; P < 0.001). The second aim of this study was to investigate the mechanisms by which ethanol suppresses PS. We examined the effects of cholinergic drug pretreatment. The cholinergic system was chosen because of the involvement of cholinergic neurotransmitters in regulating the sleep-wake cycle. A second set of animals was pretreated with 2.5, 5.0, and 10 mg/kg pilocarpine (cholinergic agonist) or atropine (cholinergic antagonist). These drugs were administered 1 h prior to ethanol (3.5 g/kg) or vehicle. Treatment with atropine prior to vehicle or ethanol produced a statistically significant decrease in PS, whereas pilocarpine had no effect on minutes of PS. Although the mechanism by which ethanol induces PS suppression is not fully understood, these data suggest that the cholinergic system is not the only system involved in this interaction.en
dc.description.affiliationUniversidade Federal de São Paulo (UNIFESP) Escola Paulista de Medicina Departamento de Psicobiologia
dc.description.affiliationUnifespUNIFESP, EPM, Depto. de Psicobiologia
dc.description.sourceSciELO
dc.format.extent782-788
dc.identifierhttp://dx.doi.org/10.1590/S0100-879X2008000900007
dc.identifier.citationBrazilian Journal of Medical and Biological Research. Associação Brasileira de Divulgação Científica, v. 41, n. 9, p. 782-788, 2008.
dc.identifier.doi10.1590/S0100-879X2008000900007
dc.identifier.fileS0100-879X2008000900007.pdf
dc.identifier.issn0100-879X
dc.identifier.scieloS0100-879X2008000900007
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/4545
dc.identifier.wosWOS:000259543000003
dc.language.isoeng
dc.publisherAssociação Brasileira de Divulgação Científica
dc.relation.ispartofBrazilian Journal of Medical and Biological Research
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectCholinergicen
dc.subjectAtropineen
dc.subjectPilocarpineen
dc.subjectEthanolen
dc.subjectParadoxical sleepen
dc.subjectElectroencephalographyen
dc.titleParticipation of the cholinergic system in the ethanol-induced suppression of paradoxical sleep in ratsen
dc.typeinfo:eu-repo/semantics/article
Arquivos
Pacote Original
Agora exibindo 1 - 1 de 1
Imagem de Miniatura
Nome:
S0100-879X2008000900007.pdf
Tamanho:
524.41 KB
Formato:
Adobe Portable Document Format
Descrição:
Baixar
Coleções
EPM - Artigos