Dermatophyte-host relationship of a murine model of experimental invasive dermatophytosis

Página do item simplificado
dc.contributor.authorVenturini, James
dc.contributor.authorAlvares, Anuska Marcelino [UNIFESP]
dc.contributor.authorCamargo, Marcela Rodrigues de
dc.contributor.authorMarchetti, Camila Martins
dc.contributor.authorFraga-Silva, Thais Fernanda de Campos
dc.contributor.authorLuchini, Ana Carolina
dc.contributor.authorArruda, Maria Sueli Parreira de
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.contributor.institutionUniv Fed Triangulo Mineiro
dc.date.accessioned2016-01-24T14:27:54Z
dc.date.available2016-01-24T14:27:54Z
dc.date.issued2012-11-01
dc.description.abstractRecognizing the invasive potential of the dermatophytes and understanding the mechanisms involved in this process will help with disease diagnosis and with developing an appropriate treatment plan. in this report, we present the histopathological, microbiological and immunological features of a model of invasive dermatophytosis that is induced by subcutaneous infection of Trichophyton mentagrophytes in healthy adult Swiss mice. Using this model, we observed that the fungus rapidly spreads to the popliteal lymph nodes, spleen, liver and kidneys. Similar to the human disease, the lymph nodes were the most severely affected sites. the fungal infection evoked acute inflammation followed by a granulomatous reaction in the mice, which is similar to what is observed in patients. the mice were able to mount a Th1-polarized immune response and displayed IL-10-mediated immune regulation. We believe that the model described here will provide valuable information regarding the dermatophyte-host relationship and will yield new perspective for a better understanding of the immunological and pathological aspects of invasive dermatophytosis. (c) 2012 Institut Pasteur. Published by Elsevier Masson SAS. All rights reserved.en
dc.description.affiliationUNESP Univ Estadual Paulista, Fac Ciencias, Dept Ciencias Biol, Lab Imunopatol Expt, BR-17033360 Bauru, SP, Brazil
dc.description.affiliationUNESP Univ Estadual Paulista, Fac Med Botucatu, BR-18618970 Botucatu, SP, Brazil
dc.description.affiliationUNIFESP Universidade Federal de São Paulo, Dept Microbiol Imunol & Parasitol, BR-04023900 São Paulo, Brazil
dc.description.affiliationUniv Fed Triangulo Mineiro, Inst Ciencias Biol & Nat, BR-38025180 Uberaba, MG, Brazil
dc.description.affiliationUnifespUNIFESP Universidade Federal de São Paulo, Dept Microbiol Imunol & Parasitol, BR-04023900 São Paulo, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipFundação para o Desenvolvimento da UNESP (FUNDUNESP)
dc.format.extent1144-1151
dc.identifierhttp://dx.doi.org/10.1016/j.micinf.2012.07.014
dc.identifier.citationMicrobes and Infection. Amsterdam: Elsevier B.V., v. 14, n. 13, p. 1144-1151, 2012.
dc.identifier.doi10.1016/j.micinf.2012.07.014
dc.identifier.fileWOS000311017000004.pdf
dc.identifier.issn1286-4579
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/35422
dc.identifier.wosWOS:000311017000004
dc.language.isoeng
dc.publisherElsevier B.V.
dc.relation.ispartofMicrobes and Infection
dc.rightsinfo:eu-repo/semantics/openAccess
dc.rights.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dc.subjectDermatophytesen
dc.subjectInvasive dermatophytosisen
dc.subjectTrichophyton mentagrophytesen
dc.subjectCellular immune responseen
dc.subjectExperimental dermatophytosisen
dc.titleDermatophyte-host relationship of a murine model of experimental invasive dermatophytosisen
dc.typeinfo:eu-repo/semantics/article
Arquivos
Pacote Original
Agora exibindo 1 - 1 de 1
Imagem de Miniatura
Nome:
WOS000311017000004.pdf
Tamanho:
1.38 MB
Formato:
Adobe Portable Document Format
Descrição:
Baixar
Coleções
EPM - Artigos