The PGE(2)/IL-10 Axis Determines Susceptibility of B-1 Cell-Derived Phagocytes (B-1CDP) to Leishmania major Infection

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dc.contributor.authorArcanjo, Angelica F.
dc.contributor.authorLaRocque-de-Freitas, Isabel F.
dc.contributor.authorRocha, Juliana Dutra B.
dc.contributor.authorZamith, Daniel
dc.contributor.authorCosta-da-Silva, Ana Caroline
dc.contributor.authorNunes, Marise Pinheiro
dc.contributor.authorMesquita-Santos, Fabio P.
dc.contributor.authorMorrot, Alexandre
dc.contributor.authorFilardy, Alessandra A.
dc.contributor.authorMariano, Mario [UNIFESP]
dc.contributor.authorBandeira-Melo, Christianne
dc.contributor.authorDosReis, George A.
dc.contributor.authorDecote-Ricardo, Debora
dc.contributor.authorFreire-de-Lima, Celio Geraldo
dc.contributor.institutionUniversidade Federal do Rio de Janeiro (UFRJ)
dc.contributor.institutionUniv Fed Rural Rio de Janeiro
dc.contributor.institutionFiocruz MS
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.date.accessioned2016-01-24T14:40:25Z
dc.date.available2016-01-24T14:40:25Z
dc.date.issued2015-05-01
dc.description.abstractB-1 cells can be differentiated from B-2 cells because they are predominantly located in the peritoneal and pleural cavities and have distinct phenotypic patterns and activation properties. A mononuclear phagocyte derived from B-1 cells (B-1CDP) has been described. As the B-1CDP cells migrate to inflammatory/infectious sites and exhibit phagocytic capacity, the microbicidal ability of these cells was investigated using the Leishmania major infection model in vitro. the data obtained in this study demonstrate that B-1CDP cells are more susceptible to infection than peritoneal macrophages, since B-1CDP cells have a higher number of intracellular amastigotes forms and consequently release a larger number of promastigotes. Exacerbated infection by Leishmania major required lipid bodies/PGE(2) and IL-10 by B-1CDP cells. Both infection and the production of IL-10 were decreased when PGE(2) production was blocked by NSAIDs. the involvement of IL-10 in this mechanism was confirmed, since B-1CDP cells from IL-10 KO mice are more competent to control Leishmania major infection than cells from wild type mice. These findings further characterize the B-1CDP cells as an important mononuclear phagocyte that plays a previously unrecognized role in host responses to Leishmania major infection, most likely via PGE(2)-driven production of IL-10.en
dc.description.affiliationUniv Fed Rio de Janeiro, Inst Biofis Carlos Chagas Filho, BR-21941 Rio de Janeiro, Brazil
dc.description.affiliationUniv Fed Rural Rio de Janeiro, Dept Vet, Rio de Janeiro, Brazil
dc.description.affiliationFiocruz MS, Inst Oswaldo Cruz, BR-21045900 Rio de Janeiro, Brazil
dc.description.affiliationUniv Fed Rio de Janeiro, Inst Microbiol Paulo de Goes, BR-21941 Rio de Janeiro, Brazil
dc.description.affiliationUniversidade Federal de São Paulo, Dept Microbiol Imunol & Parasitol, São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Dept Microbiol Imunol & Parasitol, São Paulo, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado do Rio de Janeiro (FAPERJ)
dc.format.extent18
dc.identifierhttp://dx.doi.org/10.1371/journal.pone.0124888
dc.identifier.citationPlos One. San Francisco: Public Library Science, v. 10, n. 5, 18 p., 2015.
dc.identifier.doi10.1371/journal.pone.0124888
dc.identifier.fileWOS000353887100062.pdf
dc.identifier.issn1932-6203
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/39018
dc.identifier.wosWOS:000353887100062
dc.language.isoeng
dc.publisherPublic Library Science
dc.relation.ispartofPlos One
dc.rightsinfo:eu-repo/semantics/openAccess
dc.titleThe PGE(2)/IL-10 Axis Determines Susceptibility of B-1 Cell-Derived Phagocytes (B-1CDP) to Leishmania major Infectionen
dc.typeinfo:eu-repo/semantics/article
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