Obsessive-compulsive disorder: Influence of age at onset on comorbidity patterns

dc.contributor.authorMathis, Maria Alice de
dc.contributor.authorRosario, Maria Conceicao do [UNIFESP]
dc.contributor.authorDiniz, Juliana Belo
dc.contributor.authorTorres, Albina Rodrigues
dc.contributor.authorShavitt, Roseli Gedanki
dc.contributor.authorFerrao, Ygor Arzeno
dc.contributor.authorFossaluza, Victor
dc.contributor.authorBraganca Pereira, Carlos Alberto de
dc.contributor.authorMiguel, Euripedes Constantino
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.contributor.institutionPorto Alegre Inst Univ Ctr
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.description.abstractPurpose. - This study investigates the influence of age at onset of OCS on psychiatric comorbidities, and tries to establish a cut-off point for age at onset.Methods. - Three hundred and thirty OCD patients were consecutively recruited and interviewed using the following structured interviews: Yale-Brown Obsessive Compulsive Scale; Yale Global Tic Severity Scale and the Structured Clinical Interview for DSM-IV. Data were analyzed with regression and cluster analysis.Results. - Lower age at onset was associated with a higher probability of having comorbidity with tic, anxiety, somatoform, eating and impulse-control disorders. Longer illness duration was associated with lower chance of having tics. Female gender was associated with anxiety, eating and impulse-control disorders. Tic disorders were associated with anxiety disorders and attention-deficit/hyperactivity disorder. No cutoff age at onset was found to clearly divide the sample in homogeneous subgroups. However, cluster analyses revealed that differences started to emerge at the age of 10 and were more pronounced at the age of 17, suggesting that these were the best cut-off points on this sample.Conclusions. - Age at onset is associated with specific comorbidity patterns in OCD patients. More prominent differences are obtained when analyzing age at onset as an absolute value. (C) 2008 Elsevier Masson SAS. All rights reserved.en
dc.description.affiliationUniv São Paulo, Sch Med, Dept Psychiat, BR-05403010 São Paulo, Brazil
dc.description.affiliationBotucatu Med Sch, Dept Neurol & Psychiat, Botucatu, SP, Brazil
dc.description.affiliationPorto Alegre Inst Univ Ctr, Porto Alegre, RS, Brazil
dc.description.affiliationUniv São Paulo, Math & Stat Inst, BR-05508 São Paulo, Brazil
dc.description.affiliationUniversidade Federal de São Paulo, Dept Psychiat, São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Dept Psychiat, São Paulo, Brazil
dc.description.sourceWeb of Science
dc.identifier.citationEuropean Psychiatry. Paris: Elsevier France-editions Scientifiques Medicales Elsevier, v. 23, n. 3, p. 187-194, 2008.
dc.publisherElsevier B.V.
dc.relation.ispartofEuropean Psychiatry
dc.rightsAcesso restrito
dc.subjectobsessive-compulsive disorderen
dc.subjectage at onseten
dc.subjectearly onseten
dc.subjectlate onseten
dc.titleObsessive-compulsive disorder: Influence of age at onset on comorbidity patternsen