Cellular death but not genetic damage in oral mucosa cells after exposure to digital lateral radiography

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dc.contributor.authorRibeiro, Daniel Araki [UNIFESP]
dc.contributor.authorSannomiya, Eduardo Kazuo
dc.contributor.authorPozzi, Renan [UNIFESP]
dc.contributor.authorMiranda, Sandra Regina [UNIFESP]
dc.contributor.authorAngelieri, Fernanda
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.contributor.institutionSão Paulo Methodist Univ
dc.date.accessioned2016-01-24T14:16:48Z
dc.date.available2016-01-24T14:16:48Z
dc.date.issued2011-06-01
dc.description.abstractThe aim of the present study was to evaluate DNA damage (micronucleus) and cellular death (pyknosis, karyolysis, and karyorrhexis) in exfoliated buccal mucosa cells from individuals following digital lateral radiography. A total of 30 healthy patients (15 men and 15 women) indicated to the orthodontic therapy were submitted to digital lateral X-ray. Exfoliated oral mucosa cells were collected immediately before the X-ray exposure and after 10 days. the results pointed out no significant statistically differences (p > 0.05) of micronucleated oral mucosa cells. On the other hand, X-ray was able to increase other nuclear alterations closely related to cytotoxicity such as karyorrhexis, pyknosis, and karyolysis. in summary, these data indicate that exposure to digital lateral radiography may not be a factor that induced chromosomal damage, but it is able to promote cytotoxicity.en
dc.description.affiliationUniversidade Federal de São Paulo UNIFESP, Dept Biociencias, BR-11060001 São Paulo, Brazil
dc.description.affiliationUniversidade Federal de São Paulo, Dept Patol, São Paulo, Brazil
dc.description.affiliationSão Paulo Methodist Univ, Dept Dentomaxillofacial Radiol, UMESP, São Paulo, Brazil
dc.description.affiliationSão Paulo Methodist Univ, Dept Orthodont, UMESP, São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo UNIFESP, Dept Biociencias, BR-11060001 São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Dept Patol, São Paulo, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.description.sponsorshipIDFAPESP: 07/01228-4
dc.format.extent357-360
dc.identifierhttps://dx.doi.org/10.1007/s00784-010-0402-1
dc.identifier.citationClinical Oral Investigations. Heidelberg: Springer Heidelberg, v. 15, n. 3, p. 357-360, 2011.
dc.identifier.doi10.1007/s00784-010-0402-1
dc.identifier.issn1432-6981
dc.identifier.urihttps://repositorio.unifesp.br/handle/11600/33741
dc.identifier.wosWOS:000290313400009
dc.language.isoeng
dc.publisherSpringer
dc.relation.ispartofClinical Oral Investigations
dc.rightsAcesso restrito
dc.rights.licensehttp://www.springer.com/open+access/authors+rights?SGWID=0-176704-12-683201-0
dc.subjectBuccal mucosa cellsen
dc.subjectDigital lateral radiographen
dc.subjectMicronucleus testen
dc.titleCellular death but not genetic damage in oral mucosa cells after exposure to digital lateral radiographyen
dc.typeArtigo
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