Effect of hormonal replacement therapy in the hippocampus of ovariectomized epileptic female rats using the pilocarpine experimental model

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dc.contributor.authorValente, S. G. [UNIFESP]
dc.contributor.authorMarques, R. H.
dc.contributor.authorBaracat, E. C.
dc.contributor.authorCavalheiro, E. A.
dc.contributor.authorNaffah-Mazzacoratti, M. G.
dc.contributor.authorAmado, D.
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.date.accessioned2016-01-24T13:51:51Z
dc.date.available2016-01-24T13:51:51Z
dc.date.issued2008-11-01
dc.description.abstractAmado and Cavalheiro [Amado, D., Cavatheiro, E.A., 1998. Hormonal and gestational parameters in female rats submitted to the pilocarpine model of epilepsy. Epilepsy Res. 32, 266-274], studying the establishment of the pilocarpine epilepsy model in female rats observed that the estrous cycle was dramatically altered during the three periods of this experimental model. This work was delineated to study the function of sexual hormones in the development of the epilepsy model induced by pilocarpine in ovariectomized rats. Experimental groups were: (a) control animals during estrus phase of the estrous cycle (E) and ovariectomized female rats (OVX) treated with saline instead of pilocarpine in the same volume, (b) experimental animals, that developed status epilepticus (SE) and were studied during the chronic phase of this model: intact chronic rats (CHRON) and ovariectomized chronic rats (CVX+CHRON) and (c) ovariectomized chronic rats, that were submitted to hormonal replacement therapy treated with: medroxyprogesterone (OVX + CHRON + MPA); 17 beta-estradiol (OVX + CHRON + E2), or both (OVX + CHRON + E2 + MPA). All ovariectomized animals showed genital atrophy 4 days after the surgical procedure. Moreover, all animals that developed SE and survived showed spontaneous recurrent seizures during the chronic phase. Concerning to seizure frequency, animals receiving medroxyprogesterone associated with 17 beta-estradiol showed decreased seizures' number. However, animals that received only medroxyprogesterone therapy also showed reduction in the number of seizures. in addition, hormonal treatment was also able to stabilize the mossy fibers sprouting process, showing the importance of these hormones in the development of the epilepsy in female rats. (C) 2008 Elsevier B.V. All rights reserved.en
dc.description.affiliationUniversidade Federal de São Paulo, Escola Paulista Med, Dept Ortopedia & Traumatol, São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Escola Paulista Med, Dept Ortopedia & Traumatol, São Paulo, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipPRONEX
dc.description.sponsorshipFADA
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.format.extent46-56
dc.identifierhttp://dx.doi.org/10.1016/j.eplepsyres.2008.07.003
dc.identifier.citationEpilepsy Research. Amsterdam: Elsevier B.V., v. 82, n. 1, p. 46-56, 2008.
dc.identifier.doi10.1016/j.eplepsyres.2008.07.003
dc.identifier.issn0920-1211
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/31007
dc.identifier.wosWOS:000261634000007
dc.language.isoeng
dc.publisherElsevier B.V.
dc.relation.ispartofEpilepsy Research
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.rights.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dc.subjectEpilepsyen
dc.subjectOvariectomyen
dc.subjectHippocampusen
dc.subjectPilocarpine and Hormonal replacement therapyen
dc.titleEffect of hormonal replacement therapy in the hippocampus of ovariectomized epileptic female rats using the pilocarpine experimental modelen
dc.typeinfo:eu-repo/semantics/article
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