FEV1 Is a Better Predictor of Mortality than FVC: the PLATINO Cohort Study

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dc.contributor.authorMenezes, Ana Maria B.
dc.contributor.authorPerez-Padilla, Rogelio
dc.contributor.authorWehrmeister, Fernando Cesar
dc.contributor.authorLopez-Varela, Maria Victorina
dc.contributor.authorMuino, Adriana
dc.contributor.authorValdivia, Gonzalo
dc.contributor.authorLisboa, Carmen
dc.contributor.authorJardim, Jose Roberto B. [UNIFESP]
dc.contributor.authorOca, Maria Montes de
dc.contributor.authorTalamo, Carlos
dc.contributor.authorBielemann, Renata
dc.contributor.authorGazzotti, Mariana [UNIFESP]
dc.contributor.authorLaurenti, Ruy
dc.contributor.authorCelli, Bartolome
dc.contributor.authorVictoria, Cesar G.
dc.contributor.authorPLATINO Team
dc.contributor.institutionUniv Fed Pelotas
dc.contributor.institutionNatl Inst Resp Dis Sleep Clin & Pulm Physiol
dc.contributor.institutionUniv Republica
dc.contributor.institutionCtr Hosp Pereira Rossell
dc.contributor.institutionPontificia Univ Catolica Chile
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.contributor.institutionCent Univ Venezuela
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.contributor.institutionSt Elizabeths Med Ctr
dc.date.accessioned2016-01-24T14:38:00Z
dc.date.available2016-01-24T14:38:00Z
dc.date.issued2014-10-06
dc.description.abstractObjective: To determine whether the presence of chronic obstructive lung disease (COPD) and reduction of lung function parameters were predictors of mortality in a cohort.Materials/Patients and Methods: Population based cohorts were followed in Montevideo, Santiago and São Paulo during 5, 6 and 9 years, respectively. Outcomes included all-cause, cardiovascular, respiratory and cancer mortality; exposures were COPD, forced expiratory volume in one second (FEV1) and forced vital capacity (FVC). Cox regression was used for analyses. Sensitivity, specificity, positive and negative predictive values, receiver operator characteristics curves and Youden's index were calculated.Results: Main causes of death were cardiovascular, respiratory and cancer. Baseline COPD was associated with overall mortality (HR = 1.43 for FEV1/FVC<LLN; 2.01 for GOLD 2-4; 1.46 for GOLD 1-4; 1.50 for FEV1/FEV6 <LLN). for cardiovascular mortality, significant associations were found with GOLD 2-4 (HR = 2.68) and with GOLD 1-4 (HR = 1.78) for both genders together (not among women). Low FEV1 was risk for overall and respiratory mortality (both genders combined). FVC was not associated with overall mortality. for most COPD criteria sensitivity was low and specificity high. the area under the curve for FEV1 was greater than for FVC for overall and cardiovascular mortality.Answer to the Question: COPD and low FEV1 are important predictors for overall and cardiovascular mortality in Latin America.en
dc.description.affiliationUniv Fed Pelotas, Postgrad Program Epidemiol, Pelotas, Brazil
dc.description.affiliationNatl Inst Resp Dis Sleep Clin & Pulm Physiol, Mexico City, DF, Mexico
dc.description.affiliationUniv Republica, Fac Med, Montevideo, Uruguay
dc.description.affiliationCtr Hosp Pereira Rossell, Montevideo, Uruguay
dc.description.affiliationPontificia Univ Catolica Chile, Santiago, Chile
dc.description.affiliationUniversidade Federal de São Paulo, São Paulo, Brazil
dc.description.affiliationCent Univ Venezuela, Fac Med, Caracas, Venezuela
dc.description.affiliationUniv São Paulo, São Paulo, Brazil
dc.description.affiliationSt Elizabeths Med Ctr, Boston, MA USA
dc.description.affiliationUnifespUniversidade Federal de São Paulo, São Paulo, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipThe Asociacion Latinoamericana de Torax (ALAT)
dc.description.sponsorshipBoehringer Ingelheim GmbH
dc.description.sponsorshipGlaxoSmithKline
dc.description.sponsorshipNovartis
dc.format.extent10
dc.identifierhttp://dx.doi.org/10.1371/journal.pone.0109732
dc.identifier.citationPlos One. San Francisco: Public Library Science, v. 9, n. 10, 10 p., 2014.
dc.identifier.doi10.1371/journal.pone.0109732
dc.identifier.fileWOS000345743700087.pdf
dc.identifier.issn1932-6203
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/38323
dc.identifier.wosWOS:000345743700087
dc.language.isoeng
dc.publisherPublic Library Science
dc.relation.ispartofPlos One
dc.rightsinfo:eu-repo/semantics/openAccess
dc.titleFEV1 Is a Better Predictor of Mortality than FVC: the PLATINO Cohort Studyen
dc.typeinfo:eu-repo/semantics/article
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