Do sleep abnormalities and misaligned sleep/circadian rhythm patterns represent early clinical characteristics for developing psychosis in high risk populations?

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dc.contributor.authorZanini, Marcio [UNIFESP]
dc.contributor.authorCastro, Juliana [UNIFESP]
dc.contributor.authorCoelho, Fernando Morgadinho [UNIFESP]
dc.contributor.authorBittencourt, Lia [UNIFESP]
dc.contributor.authorBressan, Rodrigo A. [UNIFESP]
dc.contributor.authorTufik, Sergio [UNIFESP]
dc.contributor.authorBrietzke, Elisa [UNIFESP]
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.date.accessioned2016-01-24T14:34:49Z
dc.date.available2016-01-24T14:34:49Z
dc.date.issued2013-12-01
dc.description.abstractSleep architecture changes, such as slow-wave sleep (SWS) percentage variations and reductions in latency and density of rapid eye movement (REM), are found in most patients with schizophrenia and are considered to be an important part of the pathophysiology of the disorder. in addition to these sleep parameters changes, disruptions in sleep homeostasis and the sleep/circadian rhythm also occur in these patients. Sleep/circadian rhythm abnormalities negatively affect neocortical plasticity and cognition and often precede the diagnosis of the illness. Thus, it has been suggested that the sleep/circadian rhythm might be involved in the pathophysiology of psychosis.Recent advances in the identification of individuals at a high risk for developing schizophrenia allow us to investigate several neurobiological processes involved in the development of psychosis. in this article, we review the current evidence of the effects of sleep parameter abnormalities, disruptions in sleep homeostasis and misalignments of sleep circadian rhythm on the early stages of schizophrenia. in addition, we discuss the preliminary evidence of sleep and circadian rhythm abnormalities during the prodromal stages of psychosis and propose that these abnormalities can be explored as potential predictors, as an adjunct to clinical diagnosis, of developing a psychotic disorder in at risk populations. (C) 2013 Elsevier B.V. All rights reserved.en
dc.description.affiliationUniversidade Federal de São Paulo, Programa Reconhecimento & Intervencao Individuos, Dept Psiquiatria, São Paulo, Brazil
dc.description.affiliationUniversidade Federal de São Paulo, Dept Psiquiatria, Lab Interdisciplinar Neurociencias Clin, São Paulo, Brazil
dc.description.affiliationUniversidade Federal de São Paulo, Dept Psicobiol, Disciplina Med & Biol Sono, São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Programa Reconhecimento & Intervencao Individuos, Dept Psiquiatria, São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Dept Psiquiatria, Lab Interdisciplinar Neurociencias Clin, São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Dept Psicobiol, Disciplina Med & Biol Sono, São Paulo, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipAssociacao Fundo de Incentivo a Pesquisa (AFIP)
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.format.extent2631-2637
dc.identifierhttp://dx.doi.org/10.1016/j.neubiorev.2013.08.012
dc.identifier.citationNeuroscience and Biobehavioral Reviews. Oxford: Pergamon-Elsevier B.V., v. 37, n. 10, p. 2631-2637, 2013.
dc.identifier.doi10.1016/j.neubiorev.2013.08.012
dc.identifier.issn0149-7634
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/37043
dc.identifier.wosWOS:000330490200016
dc.language.isoeng
dc.publisherElsevier B.V.
dc.relation.ispartofNeuroscience and Biobehavioral Reviews
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.rights.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dc.subjectSchizophreniaen
dc.subjectPsychosisen
dc.subjectUltra High Risken
dc.subjectSleepen
dc.subjectCircadian rhythmen
dc.titleDo sleep abnormalities and misaligned sleep/circadian rhythm patterns represent early clinical characteristics for developing psychosis in high risk populations?en
dc.typeinfo:eu-repo/semantics/article
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