SMARCA5 Methylation and Expression in Gastric Cancer

dc.contributor.authorGigek, Carolina Oliveira
dc.contributor.authorFrias Lisboa, Luara Carolina
dc.contributor.authorLeal, Mariana Ferreira
dc.contributor.authorOliveira Silva, Patricia Natalia
dc.contributor.authorLima, Eleonidas Moura
dc.contributor.authorKhayat, Andre Salim
dc.contributor.authorAssumpcao, Paulo Pimentel
dc.contributor.authorBurbano, Rommel Rodriguez
dc.contributor.authorCardoso Smith, Marilia de Arruda [UNIFESP]
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.contributor.institutionUniv Fed Piaui
dc.contributor.institutionFed Univ Para
dc.contributor.institutionHosp Univ Joao de Barros Barreto
dc.date.accessioned2016-01-24T14:06:11Z
dc.date.available2016-01-24T14:06:11Z
dc.date.issued2011-02-01
dc.description.abstractHere, we first evaluated SMARCA5 expression and promoter DNA methylation in gastric carcinogenesis. lmmunohistochemistry and methylation-specific PCR were analyzed in 19 and 48 normal mucosa and in 52 and 92 gastric cancer samples, respectively. We observed higher immunoreactivity of SMARCA5 in gastric cancer samples than in normal mucosa. Moreover, SMARCA5 promoter methylation was associated with the absence of protein expression. Our findings suggest that SMARCA5 has a potential role in proliferation and malignancy in gastric carcinogenesis.en
dc.description.affiliationUniversidade Federal de São Paulo, Escola Paulista Med, Disciplina Genet, Dept Morfol & Genet, BR-04023900 São Paulo, Brazil
dc.description.affiliationUniv Fed Piaui, Dept Biol, Teresina, Piaui, Brazil
dc.description.affiliationFed Univ Para, Lab Citogenet Humana, Inst Ciencias Biol, Belem, PA, Brazil
dc.description.affiliationHosp Univ Joao de Barros Barreto, Serv Cirurgia, Belem, Para, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Escola Paulista Med, Disciplina Genet, Dept Morfol & Genet, BR-04023900 São Paulo, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.format.extent162-166
dc.identifierhttp://dx.doi.org/10.3109/07357907.2010.543365
dc.identifier.citationCancer Investigation. London: Informa Healthcare, v. 29, n. 2, p. 162-166, 2011.
dc.identifier.doi10.3109/07357907.2010.543365
dc.identifier.issn0735-7907
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/33454
dc.identifier.wosWOS:000287171700010
dc.language.isoeng
dc.publisherInforma Healthcare
dc.relation.ispartofCancer Investigation
dc.rightsAcesso restrito
dc.rights.licensehttp://informahealthcare.com/userimages/ContentEditor/1255620309227/Copyright_And_Permissions.pdf
dc.subjectEpigeneticen
dc.subjectDNA methylationen
dc.subjectProtein expressionen
dc.subjectIHCen
dc.subjectSMARCA5en
dc.titleSMARCA5 Methylation and Expression in Gastric Canceren
dc.typeArtigo
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